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The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil
Gao, Ying; Chen, Min; Ye, Hua; Guo, Xiao-Hui; Zhao, Ming-hui; Wang, Hai-yan
关键词Antineutrophil Cytoplasmic Antibodies Vasculitis Propylthiouracil Hyperthyroidism Target Antigen
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
2007
DOI10.1016/j.intimp.2006.07.033
7期:1页:55-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Pharmacology & Pharmacy
研究领域[WOS]Immunology ; Pharmacology & Pharmacy
关键词[WOS]OF-THE-LITERATURE ; ANTITHYROID DRUGS ; AUTOANTIBODIES ANCA ; SYSTEMIC VASCULITIS ; POSITIVE VASCULITIS ; INCREASING PROTEIN ; CHINESE PATIENTS ; GRAVES-DISEASE ; MYELOPEROXIDASE ; HYPERTHYROIDISM
英文摘要

Objective: Antineutrophil cytoplasmic antibody (ANCA) has been well documented in association with propylthiouracil (PTU), and some patients with PTU-induced ANCA also develop clinical vasculitis. The aim of the current study was to detect ANCA specificities in sera from patients with PTU-induced ANCA with and without clinical vasculitis.

Methods: Sera from 65 patients with PTU-induced ANCA were collected, and 27 of these patients were diagnosed with PTU-induced ANCA associated systemic vasculitis (AASV). Indirect immunofluorescence assay and antigen-specific ELISAs were used to detect ANCA and their antigen specificities. The seven known target antigens included myeloperoxidase (MPO), protemase 3, human leukocyte elastase, lactoferrin, cathepsin G, azurocidin and bactericidal/pen-neability-increasing protein (BPI).

Results: In IIF assay, P-ANCA was found in 58/65 (89.2%) sera, C-ANCA in two, both P-ANCA and C-ANCA in five, respectively. MPO (60%) and lactoferrin (63.1%) were the two most common target antigens detected in sera from all the patients. 25/27 sera from patients with PTU-induced AASV recognized multiple target antigens, which was significantly higher than those (13/38) from patients without (P < 0.001). Except anti-BPI antibodies, the prevalence of antibodies against the other six target antigens was significantly higher in patients with clinical vasculitis than that in patients without (P < 0.05, respectively).

Conclusion: Antibodies against multiple ANCA specific antigens, especially the antigens rather than MPO and PR3, might be the characteristic of PTU-induced ANCA. Patients with antibodies against more ANCA specific antigens might be at increased risk of developing overt clinical vasculitis. The mechanism of ANCA production in PTU-induced cases was different from that in primary AASV (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000243286100007
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54828
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, First Hosp, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Dept Endocrinol, Beijing 100034, Peoples R China
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GB/T 7714
Gao, Ying,Chen, Min,Ye, Hua,et al. The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2007,7(1):55-60.
APA Gao, Ying,Chen, Min,Ye, Hua,Guo, Xiao-Hui,Zhao, Ming-hui,&Wang, Hai-yan.(2007).The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil.INTERNATIONAL IMMUNOPHARMACOLOGY,7(1),55-60.
MLA Gao, Ying,et al."The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil".INTERNATIONAL IMMUNOPHARMACOLOGY 7.1(2007):55-60.
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