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学科主题: 基础医学
题名:
Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis
作者: Liao, Qinyuan1,2; Liu, Wei1,2; Liu, Yang1,2; Wang, Fulin4; Wang, Chong1,2; Zhang, Jingxuan3; Chu, Ming1,2; Jiang, Dongyang1,2; Xiao, Lin1,2; Shao, Wenwei1,2; Sheng, Zhengzuo1; Tao, Xia5; Huo, Lei6; Yin, C. Cameron7; Zhang, Youhui8; Lee, Gregory9; Huang, Jing1,2; Li, Zihai10; Qiu, Xiaoyan1,2,3
关键词: nanIgG ; RP215 ; epithelial stem/progenitor-like cells ; tumor metastasis
刊名: ONCOTARGET
发表日期: 2015-11-24
卷: 6, 期:37, 页:40081-40094
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: PAN CANCER MARKER ; BREAST-CANCER ; STEM-CELLS ; MONOCLONAL-ANTIBODY ; POOR-PROGNOSIS ; CHAIN GENE ; CARCINOMAS ; SUBTYPE ; REARRANGEMENT ; MECHANISMS
英文摘要:

High expression of immunoglobulin G (IgG) in many non-B cell malignancies and its non-conventional roles in promoting proliferation and survival of cancer cells have been demonstrated. However, the precise function of non-B IgG remains incompletely understood. Here we define the antigen specificity of RP215, a monoclonal antibody that specifically recognizes the IgG in cancer cells. Using RP215, our study shows that IgG is overexpressed in cancer cells of epithelial lineage, especially cells with cancer stem/progenitor cell-like features. The RP215-recognized IgG is primarily localized on the cell surface, particularly lamellipodia-like structures. Cells with high IgG display higher migration, increased invasiveness and metastasis, and enhanced self-renewal and tumorgenecity ability in vitro and in vivo. Importantly, depletion of IgG in breast cancer leads to reduced adhesion, invasion and self-renewal and increased apoptosis of cancer cells. We conclude that high expression of IgG is a novel biomarker of tumor progression, metastasis and cancer stem cell maintenance and demonstrate the potential therapeutic benefits of RP215-recognized IgG targeted strategy.

语种: 英语
所属项目编号: 81272237 ; 91229102 ; 81320108020 ; 7112082
项目资助者: National Nature Science Foundation of China ; Natural Science Foundation of Beijing
WOS记录号: WOS:000366114400055
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54831
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
5.Peking Univ, Hosp 1, Dept Gynecol, Beijing 100034, Peoples R China
6.Univ Texas MD Anderson Canc Ctr, Div Pathol & Lab Med, Houston, TX 77030 USA
7.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
8.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Immunol, Beijing 100021, Peoples R China
9.Univ British Columbia, Ctr Reprod Hlth, Androl Lab, Vancouver, BC V5Z 4H4, Canada
10.Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

Recommended Citation:
Liao, Qinyuan,Liu, Wei,Liu, Yang,et al. Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis[J]. ONCOTARGET,2015,6(37):40081-40094.
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