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Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto′s thyroiditis with different thyroid functional status
Xie, L. -D.; Gao, Y.; Li, M. -R.; Lu, G. -Z.; Guo, X. -H.
关键词Anti-thyroid Peroxidase Antibody Hashimoto&Prime s Thyroiditis Igg Subclass
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2008-11-01
DOI10.1111/j.1365-2249.2008.03756.x
154期:2页:172-176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GOITROUS AUTOIMMUNE-THYROIDITIS ; CELL-MEDIATED CYTOTOXICITY ; IGG SUBCLASSES ; AUTOANTIBODIES ; THYROGLOBULIN ; COMPLEMENT ; SET
英文摘要

The mechanism of disease progression in Hashimoto′s thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status. Sera from 168 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (n = 66), subclinical hypothyroidism (n = 60) and euthyroidism (n = 42). Antigen-specific enzyme-linked immunosorbent assay was used to detect the distribution of TPOAb IgG subclasses. The prevalence of TPOAb IgG subclasses in all patients′ sera with HT was IgG1 70.2%, IgG2 35.1%, IgG3 19.6% and IgG4 66.1% respectively. The prevalence of IgG2 in sera from patients with hypothyroidism (51.5%) was significantly higher than that of subclinical hypothyroidism (33.3%) (P < 0.05), and the latter was also significantly higher than that of euthyroidism (11.9%) (P < 0.05). The positive percentage of IgG2 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism (P < 0.05), the prevalence and positive percentage of IgG4 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism respectively (P < 0.05). The predominant TPOAb IgG subclasses in sera from patients with HT were IgG1 and IgG4. Patients with high levels of TPOAb IgG2, IgG4 subclasses might be at high risk of developing overt hypothyroidism.

语种英语
WOS记录号WOS:000259814300003
项目编号7082096
资助机构the Beijing Natural Science Foundation
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54836
专题北京大学第一临床医学院_内分泌内科
作者单位Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xie, L. -D.,Gao, Y.,Li, M. -R.,et al. Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto&prime;s thyroiditis with different thyroid functional status[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2008,154(2):172-176.
APA Xie, L. -D.,Gao, Y.,Li, M. -R.,Lu, G. -Z.,&Guo, X. -H..(2008).Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto′s thyroiditis with different thyroid functional status.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,154(2),172-176.
MLA Xie, L. -D.,et al."Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto′s thyroiditis with different thyroid functional status".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 154.2(2008):172-176.
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