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学科主题: 药学
题名:
Gas-fragmentation study of the novel synthetic zwitterionic drug 3-methyl-9-(2-oxa-2 lambda 5-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro[5,5]undecane chloride (SLXM-2) by electrospray ionization tandem mass spectrometry
作者: Wang, Siting2; Song, Yan1; Wang, Jiao2; Ling, Xiaomei1,2; Ge, Zemei1; Li, Runtao1; Cui, Jingrong1
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2010-04-01
DOI: 10.1002/rcm.4501
卷: 24, 期:8, 页:1181-1184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Spectroscopy
研究领域[WOS]: Chemistry ; Spectroscopy
关键词[WOS]: HUMAN PLASMA ; CYCLOPHOSPHAMIDE ; METABOLITES
英文摘要:

The zwitterionic drug 3-methyl-9-(2-oxa-2 lambda 5-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspirol-5,5]undecane chloride (SLXM-2) is a novel synthetic compound which has shown anticancer activity and low toxicity in viva. In this study, the various gas-phase fragmentation routes were analyzed by electrospray ionization mass spectrometry (positive ion mode) in conjunction with tandem mass spectrometry (ESI-MS(n)) for the first time. In ESI-MS the fragment ion at m/z 289 (base peak) was formed by loss of the chlorine anion from the zwitterionic precursor SLXM-2. The fragment ion at m/z 232 was formed from the ion at m/z 289 by loss of 1-methylaziridine. The detailed gas-phase collision-induced dissociation (CID) fragmentation mechanisms obtained from the various precursor ions extracted from the zwitterionic SLXM-2 drug was obtained by tandem mass spectrometry analyses. Copyright (C) 2010 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 7102107 ; K20090207 ; 2009ZX09301-010
项目资助者: Natural Science Foundation of Beijing ; Open Foundation of State Key Laboratory of Natural and Biomimetic Drugs ; National New Drug Research and Development Project
WOS记录号: WOS:000276775700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54838
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Siting,Song, Yan,Wang, Jiao,et al. Gas-fragmentation study of the novel synthetic zwitterionic drug 3-methyl-9-(2-oxa-2 lambda 5-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro[5,5]undecane chloride (SLXM-2) by electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2010,24(8):1181-1184.
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