IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
PPM1B negatively regulates antiviral response via dephosphorylating TBK1
Zhao, Yanling1,2; Liang, Li3,4; Fan, Yihui1; Sun, Surong5; An, Lei4; Shi, Zhongcheng6; Cheng, Jin1,7; Jia, Wei4,8; Sun, Wenjing1,2; Mori-Akiyama, Yuko6; Zhang, Hong4; Fu, Songbin2; Yang, Jianhua1
关键词Ppm1b Tbk1 Phosphatase Antiviral Response
刊名CELLULAR SIGNALLING
2012-11-01
DOI10.1016/j.cellsig.2012.06.017
24期:11页:2197-2204
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]I-LIKE RECEPTORS ; NF-KAPPA-B ; ADAPTER PROTEIN ; INNATE IMMUNITY ; INTERFERONS ; ACTIVATION ; PATHWAY ; VIRUS ; IRF3 ; AUTOIMMUNITY
英文摘要

The production of type I interferon must be tightly regulated and aberrant production of type 1 interferon is harmful or even fatal to the host. TBK1 phosphorylation at Ser172 plays an essential role in TBK1-mediated antiviral response. However, how TBK1 activity is negatively regulated remains poorly understood. Using a functional genomics approach, we have identified PPM1B as a TBK1 phosphatase. PPM1B dephosphorylates TBK1 in vivo and in vitro. PPM1B wild-type but not its phosphatase-deficient R179G mutant inhibits TBK1-mediated antiviral response and facilitates VSV replication in the cells. Viral infection induces association of PPM1B with TBK1 in a transient fashion in the cells. Conversely, suppression of PPM1B expression enhances virus-induced IRF3 phosphorylation and IFN beta production. Our study identifies a previously unrecognized role for PPM1B in the negative regulation of antiviral response by acting as a TBK1 phosphatase. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000309309100024
项目编号1R01NS072420-01
资助机构NIH/NINDS ; Virginia &amp ; L E Simmons Family Foundation Collaborative Research Fund
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54839
专题北京大学第三临床医学院
北京大学第三临床医学院_肿瘤治疗中心
作者单位1.Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pediat, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
2.Harbin Med Univ, Med Genet Lab, Harbin 150081, Peoples R China
3.Peking Univ, Dept Tumor Chemotherapy & Radiat Sickness, Hosp 3, Beijing 100191, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
5.Xinjiang Univ, Xinjiang Key Lab Biol Resources & Genet Engn, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
6.Baylor Coll Med, Dept Pathol & Immunol, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
7.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
8.Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yanling,Liang, Li,Fan, Yihui,et al. PPM1B negatively regulates antiviral response via dephosphorylating TBK1[J]. CELLULAR SIGNALLING,2012,24(11):2197-2204.
APA Zhao, Yanling.,Liang, Li.,Fan, Yihui.,Sun, Surong.,An, Lei.,...&Yang, Jianhua.(2012).PPM1B negatively regulates antiviral response via dephosphorylating TBK1.CELLULAR SIGNALLING,24(11),2197-2204.
MLA Zhao, Yanling,et al."PPM1B negatively regulates antiviral response via dephosphorylating TBK1".CELLULAR SIGNALLING 24.11(2012):2197-2204.
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