IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科
学科主题临床医学
Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups
Wu, Chang-Yi1; Bermudez-Humaran, Luis G.2,3; Yue, Feng1; Li, Min1; Zhang, Li-Ping1
关键词Heme Oxygenase-1 Hyperoxic Lung Injury Inflammation Lactic Acid Bacteria Lactococcus Lactis
刊名BIOTECHNOLOGY LETTERS
2015-06-01
DOI10.1007/s10529-015-1795-3
37期:6页:1203-1211
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]PROTEIN-KINASE PATHWAY ; CARBON-MONOXIDE ; EPITHELIAL-CELLS ; REACTIVE OXYGEN ; INJURY ; PROTECTION ; TOXICITY ; ADULT ; MICE
英文摘要

To evaluate the effects of a recombinant strain of Lactococcus lactis secreting bioactive heme oxygenase-1 (LL-HO-1) in a model of hyperoxia-induced lung injury in rat pups

Intranasal administration with LL-HO-1 significantly reduced hyperoxia-induced lung injury as demonstrated by a decreased wet/dry ratio, myeloperoxidase activity in lung tissue, tumor necrosis factor alpha levels in bronchoalveolar lavage (BAL) fluid, and attenuated lung injury scores. Although expression of HO-1 and NADPH oxidase-1 and production of superoxide in lung tissue were not affected by LL-HO-1 treatment, HO-1 levels in nasal mucosa and interleukin-10 concentrations in BAL fluid significantly increased compared with the hyperoxia control group

Intranasal administration of LL-HO-1 protects against hyperoxia-induced lung damage, apparently through attenuation of inflammation.

语种英语
WOS记录号WOS:000354498900009
项目编号30801075
资助机构National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54840
专题北京大学第三临床医学院_麻醉科
作者单位1.AgroParisTech, UMR Micalis, F-78350 Jouy En Josas, France
2.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100191, Peoples R China
3.INRA, Micalis UMR1319, F-78350 Jouy En Josas, France
推荐引用方式
GB/T 7714
Wu, Chang-Yi,Bermudez-Humaran, Luis G.,Yue, Feng,et al. Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups[J]. BIOTECHNOLOGY LETTERS,2015,37(6):1203-1211.
APA Wu, Chang-Yi,Bermudez-Humaran, Luis G.,Yue, Feng,Li, Min,&Zhang, Li-Ping.(2015).Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups.BIOTECHNOLOGY LETTERS,37(6),1203-1211.
MLA Wu, Chang-Yi,et al."Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups".BIOTECHNOLOGY LETTERS 37.6(2015):1203-1211.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, Chang-Yi]的文章
[Bermudez-Humaran, Luis G.]的文章
[Yue, Feng]的文章
百度学术
百度学术中相似的文章
[Wu, Chang-Yi]的文章
[Bermudez-Humaran, Luis G.]的文章
[Yue, Feng]的文章
必应学术
必应学术中相似的文章
[Wu, Chang-Yi]的文章
[Bermudez-Humaran, Luis G.]的文章
[Yue, Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。