北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科  > 期刊论文
学科主题: 临床医学
题名:
Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups
作者: Wu, Chang-Yi1; Bermudez-Humaran, Luis G.2,3; Yue, Feng1; Li, Min1; Zhang, Li-Ping1
关键词: Heme oxygenase-1 ; Hyperoxic lung injury ; Inflammation ; Lactic acid bacteria ; Lactococcus lactis
刊名: BIOTECHNOLOGY LETTERS
发表日期: 2015-06-01
DOI: 10.1007/s10529-015-1795-3
卷: 37, 期:6, 页:1203-1211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
关键词[WOS]: PROTEIN-KINASE PATHWAY ; CARBON-MONOXIDE ; EPITHELIAL-CELLS ; REACTIVE OXYGEN ; INJURY ; PROTECTION ; TOXICITY ; ADULT ; MICE
英文摘要:

To evaluate the effects of a recombinant strain of Lactococcus lactis secreting bioactive heme oxygenase-1 (LL-HO-1) in a model of hyperoxia-induced lung injury in rat pups

Intranasal administration with LL-HO-1 significantly reduced hyperoxia-induced lung injury as demonstrated by a decreased wet/dry ratio, myeloperoxidase activity in lung tissue, tumor necrosis factor alpha levels in bronchoalveolar lavage (BAL) fluid, and attenuated lung injury scores. Although expression of HO-1 and NADPH oxidase-1 and production of superoxide in lung tissue were not affected by LL-HO-1 treatment, HO-1 levels in nasal mucosa and interleukin-10 concentrations in BAL fluid significantly increased compared with the hyperoxia control group

Intranasal administration of LL-HO-1 protects against hyperoxia-induced lung damage, apparently through attenuation of inflammation.

语种: 英语
所属项目编号: 30801075
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000354498900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54840
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.AgroParisTech, UMR Micalis, F-78350 Jouy En Josas, France
2.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100191, Peoples R China
3.INRA, Micalis UMR1319, F-78350 Jouy En Josas, France

Recommended Citation:
Wu, Chang-Yi,Bermudez-Humaran, Luis G.,Yue, Feng,et al. Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups[J]. BIOTECHNOLOGY LETTERS,2015,37(6):1203-1211.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Chang-Yi]'s Articles
[Bermudez-Humaran, Luis G.]'s Articles
[Yue, Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Chang-Yi]‘s Articles
[Bermudez-Humaran, Luis G.]‘s Articles
[Yue, Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace