北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科  > 期刊论文
学科主题: 临床医学
题名:
Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups
作者: Wu, Chang-Yi1; Bermudez-Humaran, Luis G.2,3; Yue, Feng1; Li, Min1; Zhang, Li-Ping1
关键词: Heme oxygenase-1 ; Hyperoxic lung injury ; Inflammation ; Lactic acid bacteria ; Lactococcus lactis
刊名: BIOTECHNOLOGY LETTERS
发表日期: 2015-06-01
DOI: 10.1007/s10529-015-1795-3
卷: 37, 期:6, 页:1203-1211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
关键词[WOS]: PROTEIN-KINASE PATHWAY ; CARBON-MONOXIDE ; EPITHELIAL-CELLS ; REACTIVE OXYGEN ; INJURY ; PROTECTION ; TOXICITY ; ADULT ; MICE
英文摘要:

To evaluate the effects of a recombinant strain of Lactococcus lactis secreting bioactive heme oxygenase-1 (LL-HO-1) in a model of hyperoxia-induced lung injury in rat pups

Intranasal administration with LL-HO-1 significantly reduced hyperoxia-induced lung injury as demonstrated by a decreased wet/dry ratio, myeloperoxidase activity in lung tissue, tumor necrosis factor alpha levels in bronchoalveolar lavage (BAL) fluid, and attenuated lung injury scores. Although expression of HO-1 and NADPH oxidase-1 and production of superoxide in lung tissue were not affected by LL-HO-1 treatment, HO-1 levels in nasal mucosa and interleukin-10 concentrations in BAL fluid significantly increased compared with the hyperoxia control group

Intranasal administration of LL-HO-1 protects against hyperoxia-induced lung damage, apparently through attenuation of inflammation.

语种: 英语
所属项目编号: 30801075
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000354498900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54840
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.AgroParisTech, UMR Micalis, F-78350 Jouy En Josas, France
2.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100191, Peoples R China
3.INRA, Micalis UMR1319, F-78350 Jouy En Josas, France

Recommended Citation:
Wu, Chang-Yi,Bermudez-Humaran, Luis G.,Yue, Feng,et al. Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups[J]. BIOTECHNOLOGY LETTERS,2015,37(6):1203-1211.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Chang-Yi]'s Articles
[Bermudez-Humaran, Luis G.]'s Articles
[Yue, Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Chang-Yi]‘s Articles
[Bermudez-Humaran, Luis G.]‘s Articles
[Yue, Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace