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学科主题: 基础医学
题名:
Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups
作者: Li, D.; Zhang, G-L.; Lou, Y-Q.; Li, Q.; Wang, X.; Bu, X-Y.
关键词: CYP3A5 ; CYP3AP1 ; Han ; Kazakh ; MDR1 ; Uygur
刊名: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
发表日期: 2007-02-01
卷: 32, 期:1, 页:89-95
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SINGLE NUCLEOTIDE POLYMORPHISMS ; P-GLYCOPROTEIN ; CYTOCHROME-P450 3A5 ; SEQUENCE DIVERSITY ; TRANSPORTER GENE ; ABCB1 MDR1 ; POPULATION ; GENOTYPE ; PHARMACOKINETICS ; PHARMACOGENETICS
英文摘要:

Background and objective: The drug transporter MDR1 and the drug metabolizing enzyme CYP3A are the two major biological factors determining the pharmacokinetics of many drugs. The functional MDR1 single nucleotide polymorphisms (SNPs) and a prevalent CYP3A5 SNP show marked interethnic variation among Orientals, Caucasians and Africans. In this study, we investigated the distribution of MDR1 and CYP3A5 SNPs among mainland Chinese Han, Uygur and Kazakh ethnic groups.

Methods: Genotypes of the MDR1 C1236T, G2677T/A and C3435T, and CYP3A5*3, CYP3AP1*3 SNPs were determined in 434 unrelated healthy subjects (165 Chinese Han, 161 Chinese Uygur and 108 Chinese Kazakh) using polymerase chain reaction followed by restriction fragment length polymorphism analysis.

Results and discussion: A significantly higher MDR1 3435T variant frequency was observed in Uygur (52.8%), than in Kazakh (39.8%) and Han (37.9%) Chinese (P < 0.01, Fisher′s exact test). There was no significant difference in MDR1 1236T and 2677T/A variant frequencies between Han, Uygur and Kazakh. CYP3A5*3 (G) allele was observed at intermediate frequencies in Uygur (84.8%) and Kazakh (86.6%), relative to Han (72.7%) and values previously reported in Caucasians (91.7%). The CYP3AP1*3 (A) allele was strongly linked to CYP3A5*3 in Chinese Han, Uygur and Kazakh.

Conclusion: Significant interethnic differences in MDR1 haplotype and CYP3A5 variant frequencies exist between mainland Chinese Han and Caucasians, and the intermediate frequencies observed in Chinese Uygur and Kazakh might be due to the genetic admixture of Eurasians and Orientals.

语种: 英语
WOS记录号: WOS:000243973800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54842
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Basic Med Sch, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Li, D.,Zhang, G-L.,Lou, Y-Q.,et al. Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups[J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS,2007,32(1):89-95.
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