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Synthesis, characterization, crystal structure and antitumor activities of a novel demethylcantharidato bridged copper(II) phenanthroline complex
Yin FuLing1; Zhu JingJing2; Hao Jian3; Cui JingRong4; Yang JunJiao3
关键词Demethylcantharidato-bridge Polymeric Copper(Ii) Complex Crystal Structure Cytotoxic Activity
刊名SCIENCE CHINA-CHEMISTRY
2013-04-01
DOI10.1007/s11426-013-4865-1
56期:4页:481-489
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者Ministry of Education of China ; Ministry of Education of China
研究领域[WOS]Chemistry
关键词[WOS]TRADITIONAL CHINESE MEDICINE ; BOVINE SERUM-ALBUMIN ; DNA-BINDING ; ANTICANCER ACTIVITY ; MAGNETIC-PROPERTIES ; DONOR LIGANDS ; DOUBLE CHAINS ; ACID ; 1,10-PHENANTHROLINE ; COORDINATION
英文摘要

A new polymeric demethylcantharidato (DCA) bridged copper(II) phenanthroline (phen) complex ([Cu(DCA)(phen)] (n) center dot nH(2)O) has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measurement, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallographic data: a = 12.4537(4) , b = 9.3897(5) , c = 30.1264(10) , and Z = 8. In the crystal structure, the octahedral coordinated copper(II) ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the CuaEuro broken vertical bar Cu separation of 6.1719 , along with phen ligands attached to both sides of the chain alternatively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evaluation of the cytotoxic activity of the copper(II) complex against HCT-8 (colorectal carcinoma), A549 (pulmonary carcinoma), HeLa (cervical cancer), HepG2 (hepatocarcinoma), BGC-823 (gastric carcinoma), and MCF-7 (breast adenocarcinoma) cell lines revealed that it is a potent cytotoxic agent, superior to Na(2)DCA and phen against HeLa, HepG2 and BGC-823 cells.

语种英语
所属项目编号20110001110054
资助者Ministry of Education of China ; Ministry of Education of China
WOS记录号WOS:000317354100012
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54844
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China
2.E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China
3.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100092, Peoples R China
4.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yin FuLing,Zhu JingJing,Hao Jian,et al. Synthesis, characterization, crystal structure and antitumor activities of a novel demethylcantharidato bridged copper(II) phenanthroline complex[J]. SCIENCE CHINA-CHEMISTRY,2013,56(4):481-489.
APA Yin FuLing,Zhu JingJing,Hao Jian,Cui JingRong,&Yang JunJiao.(2013).Synthesis, characterization, crystal structure and antitumor activities of a novel demethylcantharidato bridged copper(II) phenanthroline complex.SCIENCE CHINA-CHEMISTRY,56(4),481-489.
MLA Yin FuLing,et al."Synthesis, characterization, crystal structure and antitumor activities of a novel demethylcantharidato bridged copper(II) phenanthroline complex".SCIENCE CHINA-CHEMISTRY 56.4(2013):481-489.
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