IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study
Zhang, Chunfang1; Yu, Luping2; Xu, Tao2; Hao, Yichang2; Zhang, Xiaowei2; Liu, Zhenhua2; Xiao, Yunbei2; Wang, Xiaofeng2; Zeng, Qiang3
刊名PLOS ONE
2013-03-25
DOI10.1371/journal.pone.0059796
8期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DENSITY-LIPOPROTEIN CHOLESTEROL ; KIDNEY CANCER ; RISK-FACTORS ; MALE SMOKERS ; COHORT ; HDL ; HYPOCHOLESTEROLEMIA ; MORTALITY ; DISEASE ; DIETARY
英文摘要

Abnormal serum lipid profiles are associated with the risk of some cancers, but the direction and magnitude of the association with renal cell carcinoma is unclear. We explore the relationship between serum lipids and renal cell carcinoma via a matched case-control study. A 1:2-matched case-control study design was applied, where one renal cell carcinoma patient was matched to two non-renal-cell-carcinoma residents with respect to age (+/- 0 year) and gender. Cases (n = 248) were inpatients with a primary diagnosis of renal cell carcinoma, confirmed by pathology after operations. Controls were sampled from a community survey database matched on age and gender with cases, 2 controls for each case. Stratified Cox proportional hazard regression analysis was used to obtain hazard ratios and corresponding 95% confidence intervals of lipids level and dyslipidemia for the risk of renal cell carcinoma. Elevated serum cholesterol (p < 0.001), LDL cholesterol (p < 0.001), and HDL cholesterol (p = 0.003) are associated with decreased hazard of renal cell carcinoma, adjusting for obesity, smoke, hypertension and diabetes. However, risk caused by hTG showed no statistical significance (p = 0.263). This study indicates that abnormal lipid profile influences the risk of renal cell carcinoma.

语种英语
WOS记录号WOS:000317397200036
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54860
专题北京大学第二临床医学院
北京大学第三临床医学院_泌尿外科
作者单位1.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Int Med Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chunfang,Yu, Luping,Xu, Tao,et al. Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study[J]. PLOS ONE,2013,8(3).
APA Zhang, Chunfang.,Yu, Luping.,Xu, Tao.,Hao, Yichang.,Zhang, Xiaowei.,...&Zeng, Qiang.(2013).Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study.PLOS ONE,8(3).
MLA Zhang, Chunfang,et al."Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study".PLOS ONE 8.3(2013).
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