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学科主题: 临床医学
题名:
Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study
作者: Zhang, Chunfang1; Yu, Luping2; Xu, Tao2; Hao, Yichang2; Zhang, Xiaowei2; Liu, Zhenhua2; Xiao, Yunbei2; Wang, Xiaofeng2; Zeng, Qiang3
刊名: PLOS ONE
发表日期: 2013-03-25
DOI: 10.1371/journal.pone.0059796
卷: 8, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DENSITY-LIPOPROTEIN CHOLESTEROL ; KIDNEY CANCER ; RISK-FACTORS ; MALE SMOKERS ; COHORT ; HDL ; HYPOCHOLESTEROLEMIA ; MORTALITY ; DISEASE ; DIETARY
英文摘要:

Abnormal serum lipid profiles are associated with the risk of some cancers, but the direction and magnitude of the association with renal cell carcinoma is unclear. We explore the relationship between serum lipids and renal cell carcinoma via a matched case-control study. A 1:2-matched case-control study design was applied, where one renal cell carcinoma patient was matched to two non-renal-cell-carcinoma residents with respect to age (+/- 0 year) and gender. Cases (n = 248) were inpatients with a primary diagnosis of renal cell carcinoma, confirmed by pathology after operations. Controls were sampled from a community survey database matched on age and gender with cases, 2 controls for each case. Stratified Cox proportional hazard regression analysis was used to obtain hazard ratios and corresponding 95% confidence intervals of lipids level and dyslipidemia for the risk of renal cell carcinoma. Elevated serum cholesterol (p < 0.001), LDL cholesterol (p < 0.001), and HDL cholesterol (p = 0.003) are associated with decreased hazard of renal cell carcinoma, adjusting for obesity, smoke, hypertension and diabetes. However, risk caused by hTG showed no statistical significance (p = 0.263). This study indicates that abnormal lipid profile influences the risk of renal cell carcinoma.

语种: 英语
WOS记录号: WOS:000317397200036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54860
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Int Med Ctr, Beijing, Peoples R China

Recommended Citation:
Zhang, Chunfang,Yu, Luping,Xu, Tao,et al. Association of Dyslipidemia with Renal Cell Carcinoma: A 1:2 Matched Case-Control Study[J]. PLOS ONE,2013,8(3).
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