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学科主题: 临床医学
题名:
Permanent interstitial I-125 seed implantation as a salvage therapy for pediatric recurrent or metastatic soft tissue sarcoma after multidisciplinary treatment
作者: Yao, Lihong1; Wang, Junjie1; Jiang, Yuliang1; Li, Jinna1; Lin, Lei1; Ran, Weiqiang2; Liu, Chen3
关键词: I-125 seed ; Pediatric ; Soft tissue sarcoma ; Image guided
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2015-12-15
DOI: 10.1186/s12957-015-0747-7
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: RADIATION-THERAPY ; BRACHYTHERAPY SOURCES ; EXPERIENCE ; CARCINOMA ; RECOMMENDATIONS ; MANAGEMENT ; DOSIMETRY ; RESECTION ; CRITERIA ; HEAD
英文摘要:

Background: The management of pediatric recurrent or metastatic soft tissue sarcoma after multimodal treatment remains challenging. We investigated the feasibility, efficacy, and morbidity of permanent interstitial I-125 seed implantation under image guidance as a salvage treatment for pediatric patients with recurrent or metastatic soft tissue sarcoma.

Methods: This was a retrospective study of 10 patients who underwent percutaneous ultrasound or computed tomography (CT) guided permanent I-125 seed implantation. Postoperative dosimetry was performed for all patients. Actuarial D90 was 121-187.1 Gy (median, 170.3 Gy). The number of I-125 seeds implanted was 6-158 (median, 34.5), with a median specific activity of 0.7 mCi per seed (range, 0.62-0.8 mCi); total activity was 4.2-113.76 mCi. Followup time was 6-107 months (median, 27.5 months); no patients were lost to follow-up.

Results: The overall response rate (complete response + partial response) was 8/10 (80 %), including two patients with complete response (CR) (20 %) and five patients with partial response (PR) (60 %). Local control rates after 1 and 2 years were 70.1 and 62.3 %, respectively, with a mean local control time of 70.6 months (95 % confidence interval (CI) 45.1-96.0). Survival rates after 1 and 2 years were 68.6 and 57.1 %, respectively, with a mean survival time of 65.3 months (95 % CI 34.1-96.5). Three patients died from distant metastasis; one died from local recurrence 12 months after seed implantation. Three patients suffered a grade I skin reaction and one developed ulceration. No severe adverse neurologic sequelae or blood vessel damage occurred.

Conclusions: Image guided permanent interstitial I-125 seed implantation as a salvage treatment appears to have a satisfactory outcome in children with recurrent or metastatic soft tissue sarcoma.

语种: 英语
WOS记录号: WOS:000366713900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54867
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ultrasound, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Yao, Lihong,Wang, Junjie,Jiang, Yuliang,et al. Permanent interstitial I-125 seed implantation as a salvage therapy for pediatric recurrent or metastatic soft tissue sarcoma after multidisciplinary treatment[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2015,13.
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