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学科主题临床医学
In Vivo Study of a Self-Stabilizing Artificial Vertebral Body Fabricated by Electron Beam Melting
Yang, Jun; Cai, Hong; Lv, Jia; Zhang, Ke; Leng, Huijie; Sun, Chuiguo; Wang, Zhiguo; Liu, Zhongjun
关键词Porous Metal Electron Beam Melting 3-d Printing Vertebral Body Replacement Cervical Spine Biomaterials Ti6al4v Spine Fusion Bone Implants Biomechanics
刊名SPINE
2014-04-15
DOI10.1097/BRS.0000000000000211
39期:8页:E486-E492
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Orthopedics
研究领域[WOS]Neurosciences & Neurology ; Orthopedics
关键词[WOS]EXPANDABLE TITANIUM CAGES ; MECHANICAL-PROPERTIES ; POROUS TITANIUM ; IMPLANTS ; POROSITY ; TI6AL4V ; FUSION ; SPINE ; SUBSIDENCE ; MODEL
英文摘要

Study Design. In vivo assessment of a novel artificial vertebral body fabricated by electron beam melting (EBM) for cervical vertebral body replacement in a sheep model.

Objective. To investigate the feasibility of a novel artificial vertebral body: a "self-stabilizing artificial vertebral body" (SSAVB) fabricated by EBM in a sheep model.

Summary of Background Data. Artificial vertebral body is widely used for vertebral body replacement and spinal fusion, but research on an artificial vertebral body fabricated by EBM has not been reported.

Methods. An SSAVB made of porous Ti6Al4V was implanted into a sheep cervical spine to replace the C4 vertebral body for 6 and 12 weeks. Bone ingrowth and implant stability were radiologically evaluated, and histological and biomechanical tests were performed.

Results. No screw loosening, implant dislocation, or bone fractures occurred during the experimental period. A significant difference (P = 0.001) in bone ingrowth between the 6- and 12-week groups was noted. Comparison of the range of motion of C3-C5 segments between the in vivo group and the control groups (intact C2-C6 segment and fresh sheep cervical spines from C2 to C6 segments that underwent C4 subtotal corpectomy with the posterior vertebral wall retention by SSAVB implantation) suggests that the implant can stably replace this area of the cervical spine.

Conclusion. The open porous structure of Ti6Al4V fabricated by EBM facilitated bone ingrowth and the SSAVB can maintain cervical spine stability of the sheep. A porous metal implant can be used for load-bearing applications in a sheep model. It is hoped that these results will stimulate further study in human.

语种英语
WOS记录号WOS:000337430200002
资助机构Beijing AKEC Medical Co., Ltd ; Department of Laboratory Animal Science of Peking University Health Science Center ; School of Mechanical Engineering of Shanghai Jiao Tong University
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54873
专题北京大学第三临床医学院_骨科
北京大学第三临床医学院_耳鼻喉科
作者单位Peking Univ, Hosp 3, Dept Orthoped, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Jun,Cai, Hong,Lv, Jia,et al. In Vivo Study of a Self-Stabilizing Artificial Vertebral Body Fabricated by Electron Beam Melting[J]. SPINE,2014,39(8):E486-E492.
APA Yang, Jun.,Cai, Hong.,Lv, Jia.,Zhang, Ke.,Leng, Huijie.,...&Liu, Zhongjun.(2014).In Vivo Study of a Self-Stabilizing Artificial Vertebral Body Fabricated by Electron Beam Melting.SPINE,39(8),E486-E492.
MLA Yang, Jun,et al."In Vivo Study of a Self-Stabilizing Artificial Vertebral Body Fabricated by Electron Beam Melting".SPINE 39.8(2014):E486-E492.
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