学科主题 | 临床医学 |
A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer | |
Wang, L; Wang, J; Sun, SY; Rodriguez, M; Yue, P; Jang, SJ; Mao, L | |
关键词 | Delta Dnmt3b Nsclc Promoter Expression Splicing |
刊名 | INTERNATIONAL JOURNAL OF ONCOLOGY
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2006-07-01 | |
卷 | 29期:1页:201-207 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Oncology |
研究领域[WOS] | Oncology |
关键词[WOS] | DNA CYTOSINE-5 METHYLTRANSFERASES ; METHYLATION STATUS ; EXPRESSION ; GENE ; P16(INK4A) ; 3B |
英文摘要 | De novo promoter DNA methylation represses gene transcription and is a common mechanism to inactivate tumor suppressor genes in tumorigenesis. DNMT3B plays an important role in de novo DNA methylation. We report here the identification of a novel DNMT3B subfamily, termed Delta DNMT3B, whose expression is initiated through a promoter located at intron 4 and exon 5 of the DNMT3B gene. At least 7 transcriptional variants of Delta DNMT3B have been observed as the result of alternative pre-mRNA splicing. Predicted proteins derived from these variants suggest that 4 of the variants share a conservative enzymatic domain but contain a variable PWWP motif, a putative DNA binding structure, whereas 3 of the variants lack the enzymatic domain due to predicted premature translational termination. In non-small cell lung cancer (NSCLC) cell lines, Delta DNMT3B variants are frequently expressed and are the predominant forms of DNMT3B. Similarly, Delta DNMT3B variants are frequently expressed in primary NSCLC but are not detectable or are expressed at low levels in corresponding normal lung tissue. Our results indicate that Delta DNMT3B is the major expression form of DNMT3B in NSCLC and may play an important role in the development of aberrant promoter methylation during lung tumorigenesis. |
语种 | 英语 |
WOS记录号 | WOS:000238494800022 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/54879 |
Collection | 北京大学临床肿瘤学院_胸部肿瘤内科 |
作者单位 | 1.Emory Univ, Winship Canc Inst, Dept Oncol, Atlanta, GA 30322 USA 2.Hanyang Univ, Kuri Hosp, Dept Pathol, Seoul 471701, South Korea 3.Beijing Canc Hosp, Beijing, Peoples R China 4.Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Mol Biol Lab, Houston, TX 77030 USA 5.Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA 6.Peking Univ, Sch Oncol, Dept Thorac Med Oncol, Beijing 100871, Peoples R China |
Recommended Citation GB/T 7714 | Wang, L,Wang, J,Sun, SY,et al. A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2006,29(1):201-207. |
APA | Wang, L.,Wang, J.,Sun, SY.,Rodriguez, M.,Yue, P.,...&Mao, L.(2006).A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.INTERNATIONAL JOURNAL OF ONCOLOGY,29(1),201-207. |
MLA | Wang, L,et al."A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer".INTERNATIONAL JOURNAL OF ONCOLOGY 29.1(2006):201-207. |
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