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学科主题临床医学
A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer
Wang, L; Wang, J; Sun, SY; Rodriguez, M; Yue, P; Jang, SJ; Mao, L
关键词Delta Dnmt3b Nsclc Promoter Expression Splicing
刊名INTERNATIONAL JOURNAL OF ONCOLOGY
2006-07-01
29期:1页:201-207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DNA CYTOSINE-5 METHYLTRANSFERASES ; METHYLATION STATUS ; EXPRESSION ; GENE ; P16(INK4A) ; 3B
英文摘要

De novo promoter DNA methylation represses gene transcription and is a common mechanism to inactivate tumor suppressor genes in tumorigenesis. DNMT3B plays an important role in de novo DNA methylation. We report here the identification of a novel DNMT3B subfamily, termed Delta DNMT3B, whose expression is initiated through a promoter located at intron 4 and exon 5 of the DNMT3B gene. At least 7 transcriptional variants of Delta DNMT3B have been observed as the result of alternative pre-mRNA splicing. Predicted proteins derived from these variants suggest that 4 of the variants share a conservative enzymatic domain but contain a variable PWWP motif, a putative DNA binding structure, whereas 3 of the variants lack the enzymatic domain due to predicted premature translational termination. In non-small cell lung cancer (NSCLC) cell lines, Delta DNMT3B variants are frequently expressed and are the predominant forms of DNMT3B. Similarly, Delta DNMT3B variants are frequently expressed in primary NSCLC but are not detectable or are expressed at low levels in corresponding normal lung tissue. Our results indicate that Delta DNMT3B is the major expression form of DNMT3B in NSCLC and may play an important role in the development of aberrant promoter methylation during lung tumorigenesis.

语种英语
WOS记录号WOS:000238494800022
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54879
专题北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Emory Univ, Winship Canc Inst, Dept Oncol, Atlanta, GA 30322 USA
2.Hanyang Univ, Kuri Hosp, Dept Pathol, Seoul 471701, South Korea
3.Beijing Canc Hosp, Beijing, Peoples R China
4.Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Mol Biol Lab, Houston, TX 77030 USA
5.Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
6.Peking Univ, Sch Oncol, Dept Thorac Med Oncol, Beijing 100871, Peoples R China
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GB/T 7714
Wang, L,Wang, J,Sun, SY,et al. A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2006,29(1):201-207.
APA Wang, L.,Wang, J.,Sun, SY.,Rodriguez, M.,Yue, P.,...&Mao, L.(2006).A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.INTERNATIONAL JOURNAL OF ONCOLOGY,29(1),201-207.
MLA Wang, L,et al."A novel DNMT3B subfamily, Delta DNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer".INTERNATIONAL JOURNAL OF ONCOLOGY 29.1(2006):201-207.
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