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Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography
Wu, Huijuan1,2; de Boer, Johannes F.3; Chen, Teresa C.1
关键词Optical Coherence Tomography Retinal Nerve Fiber Layer Reproducibility Glaucoma
刊名JOURNAL OF GLAUCOMA
2011-10-01
DOI10.1097/IJG.0b013e3181f3eb64
20期:8页:470-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Ophthalmology
关键词[WOS]GLAUCOMATOUS EYES ; STRATUS OCT ; TIME-DOMAIN ; MACULAR THICKNESS ; HIGH-SPEED ; PERFORMANCE
英文摘要

Purpose: To evaluate the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained by Spectralis spectral domain optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) in normal and glaucoma participants.

Methods: Participants were recruited from a university-based clinic. Peripapillary RNFL thickness measurements were repeated 3 times during the same visit using the follow-up function. One eye of each participant was randomly selected for statistical analysis. Reproducibility was evaluated using within-subject standard deviation (Sw), coefficient of variation (CV), and intraclass correlation coefficient (ICC). Spearman rank correlation coefficient analyses were used to assess the correlation of the standard deviation of the 3 measurements for each participant with the RNFL thickness value.

Results: Forty-five normal participants and 33 glaucoma patients were included in the study. The CVs ranged from 1.45% [overall global (G)] to 2.59% [temporal quadrant (T)] in normal eyes and from 1.74% (G) to 3.22% (T) in the glaucomatous eyes. ICCs ranged from 0.977 (T) to 0.990 (G and inferior-nasal sector) in normal eyes and from 0.983 (T) to 0.997 (inferior quadrant) in glaucomatous eyes. Sw were from 1.34 mu m (G) to 2.39 mu m (superior-temporal and inferior-temporal sectors) in normal eyes and from 1.14 mu m (G) to 2.25 mu m (superior-nasal sector) in the glaucomatous eyes. There were no significant correlations between RNFL thickness values and the measurement variability for each participant.

Conclusions: Spectralis OCT shows excellent reproducibility for measuring the peripapillary RNFL thickness values in both healthy and glaucoma participants.

语种英语
所属项目编号R01 EY14975-01
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000295622500002
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54881
专题北京大学第二临床医学院_眼科
作者单位1.Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Glaucoma Serv, Boston, MA 02114 USA
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
3.Vrije Univ Amsterdam, Dept Phys & Astron, Amsterdam, Netherlands
推荐引用方式
GB/T 7714
Wu, Huijuan,de Boer, Johannes F.,Chen, Teresa C.. Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography[J]. JOURNAL OF GLAUCOMA,2011,20(8):470-476.
APA Wu, Huijuan,de Boer, Johannes F.,&Chen, Teresa C..(2011).Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography.JOURNAL OF GLAUCOMA,20(8),470-476.
MLA Wu, Huijuan,et al."Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography".JOURNAL OF GLAUCOMA 20.8(2011):470-476.
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