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学科主题: 临床医学
题名:
Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography
作者: Wu, Huijuan1,2; de Boer, Johannes F.3; Chen, Teresa C.1
关键词: optical coherence tomography ; retinal nerve fiber layer ; reproducibility ; glaucoma
刊名: JOURNAL OF GLAUCOMA
发表日期: 2011-10-01
DOI: 10.1097/IJG.0b013e3181f3eb64
卷: 20, 期:8, 页:470-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: GLAUCOMATOUS EYES ; STRATUS OCT ; TIME-DOMAIN ; MACULAR THICKNESS ; HIGH-SPEED ; PERFORMANCE
英文摘要:

Purpose: To evaluate the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained by Spectralis spectral domain optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) in normal and glaucoma participants.

Methods: Participants were recruited from a university-based clinic. Peripapillary RNFL thickness measurements were repeated 3 times during the same visit using the follow-up function. One eye of each participant was randomly selected for statistical analysis. Reproducibility was evaluated using within-subject standard deviation (Sw), coefficient of variation (CV), and intraclass correlation coefficient (ICC). Spearman rank correlation coefficient analyses were used to assess the correlation of the standard deviation of the 3 measurements for each participant with the RNFL thickness value.

Results: Forty-five normal participants and 33 glaucoma patients were included in the study. The CVs ranged from 1.45% [overall global (G)] to 2.59% [temporal quadrant (T)] in normal eyes and from 1.74% (G) to 3.22% (T) in the glaucomatous eyes. ICCs ranged from 0.977 (T) to 0.990 (G and inferior-nasal sector) in normal eyes and from 0.983 (T) to 0.997 (inferior quadrant) in glaucomatous eyes. Sw were from 1.34 mu m (G) to 2.39 mu m (superior-temporal and inferior-temporal sectors) in normal eyes and from 1.14 mu m (G) to 2.25 mu m (superior-nasal sector) in the glaucomatous eyes. There were no significant correlations between RNFL thickness values and the measurement variability for each participant.

Conclusions: Spectralis OCT shows excellent reproducibility for measuring the peripapillary RNFL thickness values in both healthy and glaucoma participants.

语种: 英语
所属项目编号: R01 EY14975-01
项目资助者: National Institutes of Health
WOS记录号: WOS:000295622500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54881
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Glaucoma Serv, Boston, MA 02114 USA
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
3.Vrije Univ Amsterdam, Dept Phys & Astron, Amsterdam, Netherlands

Recommended Citation:
Wu, Huijuan,de Boer, Johannes F.,Chen, Teresa C.. Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography[J]. JOURNAL OF GLAUCOMA,2011,20(8):470-476.
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