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Vasoactive effects of adrenotensin and its interactions with adrenomedullin
Zhou, L; Qiu, ZY; Ye, C; Di, L; Liu, XH; Tang, CS; Zhao, YT
关键词Adrenotensin Adrenomedullin Vasoactive Effects Interaction
刊名CHINESE MEDICAL JOURNAL
2000-03-01
113期:3页:269-271
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To investigate the vasoactive effects of adrenotensin and the interactions between adrenotensin and adrenomedullin (ADM).

Methods isolated rat aortic tension, rat mean arterial pressure and H-3-TdR incorporation of rat vascular smooth muscle cells were measured. Isolated rat aortas were incubated in K-H solution containing adrenomedullin or adrenotensin. The released adrenotensin or adrenomedullin tin incubation medium) from rat aortas was measured by radioimmunoassay.

Results 1 x 10(-8) and 1 x 10(-7) mol/L adrenotensin augmented rat aortic tension in a dose-dependent manner (P < 0.01). An intravenous bolus injection of adrenotensin (2.5 nmol/kg, iv) increased the mean arterial pressure by 28% in anesthetized rats (P < 0.01). 1 x 10(-7)mol/L adrenotensin increased 3H-TdR incorporation in cultured rat vascular smooth muscle cells by 55% (P < 0.01). Adrenomedullin inhibited these activities of adrenotensin to different extents. 1 x 10(-9), 1 x 10(-8) and 1 x 10(-7) mol/L adrenotensin decreased adrenomedullin release rates by 19%, 35% and 46%, respectively (P < 0.05 or P < 0.01) and 1 x 10(-8)mol/L adrenomedullin also inhibited adrenotensin release by 45% from rat aorta ( P < 0.01).

Conclusion Adrenotensin is a novel peptide that elicits the activities of vasoconstriction, presser effects and induces the proliferation of vascular smooth muscle cells. There is antagonism in vascular activities and reciprocal inhibition in the release between adrenotensin and adrenomedullin. These interactions are manifestations of intramolecular regulation of proadrenomedullin (Pro-ADM).

语种英语
WOS记录号WOS:000087103400020
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54885
专题基础医学院_心血管所
作者单位1.Chongquing Med Univ, Ctr Lab, Dept Pathophysiol, Chongqing 400016, Peoples R China
2.Beijing Med Univ, Inst Cardiovasc Res, Beijing 100083, Peoples R China
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Zhou, L,Qiu, ZY,Ye, C,et al. Vasoactive effects of adrenotensin and its interactions with adrenomedullin[J]. CHINESE MEDICAL JOURNAL,2000,113(3):269-271.
APA Zhou, L.,Qiu, ZY.,Ye, C.,Di, L.,Liu, XH.,...&Zhao, YT.(2000).Vasoactive effects of adrenotensin and its interactions with adrenomedullin.CHINESE MEDICAL JOURNAL,113(3),269-271.
MLA Zhou, L,et al."Vasoactive effects of adrenotensin and its interactions with adrenomedullin".CHINESE MEDICAL JOURNAL 113.3(2000):269-271.
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