IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation
Liu, Chen1; Jin, Rong1; Wang, Hong-Cheng2; Tang, Hui1; Liu, Yuan-Feng1; Qian, Xiao-Ping1; Sun, Xiu-Yuan1; Ge, Qing1; Sun, Xiao-Hong2; Zhang, Yu1
关键词Inhibitor of differentiation E protein CD4(+) T cell Co-stimulation T cell activation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-06-21
DOI10.1016/j.bbrc.2013.05.054
436期:1页:47-52
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institute of Health ; Beijing Natural Science Foundation ; National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institute of Health ; Beijing Natural Science Foundation
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LOOP-HELIX PROTEINS ; NF-KAPPA-B ; TRANSCRIPTION FACTORS ; LYMPHOCYTE DEVELOPMENT ; IMMUNE-SYSTEM ; RECEPTOR ; INTERLEUKIN-2 ; APOPTOSIS ; SIGNAL ; E2A
英文摘要

Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naive CD4(+) cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-kappa B activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2011CB946100 ; 30830091 ; 31000393 ; B07001 ; AI56129 ; 7132114
资助者National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institute of Health ; Beijing Natural Science Foundation ; National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institute of Health ; Beijing Natural Science Foundation
WOS记录号WOS:000321682100009
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54886
Collection北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
Recommended Citation
GB/T 7714
Liu, Chen,Jin, Rong,Wang, Hong-Cheng,et al. Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,436(1):47-52.
APA Liu, Chen.,Jin, Rong.,Wang, Hong-Cheng.,Tang, Hui.,Liu, Yuan-Feng.,...&Zhang, Yu.(2013).Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,436(1),47-52.
MLA Liu, Chen,et al."Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436.1(2013):47-52.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S0006291X1300(875KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liu, Chen]'s Articles
[Jin, Rong]'s Articles
[Wang, Hong-Cheng]'s Articles
百度学术
百度学术Similar articles in
[Liu, Chen]'s Articles
[Jin, Rong]'s Articles
[Wang, Hong-Cheng]'s Articles
必应学术
必应学术Similar articles in
[Liu, Chen]'s Articles
[Jin, Rong]'s Articles
[Wang, Hong-Cheng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0006291X13008371-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.