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学科主题基础医学
Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation
Liu, Chen1; Jin, Rong1; Wang, Hong-Cheng2; Tang, Hui1; Liu, Yuan-Feng1; Qian, Xiao-Ping1; Sun, Xiu-Yuan1; Ge, Qing1; Sun, Xiao-Hong2; Zhang, Yu1
关键词Inhibitor of differentiation E protein CD4(+) T cell Co-stimulation T cell activation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-06-21
DOI10.1016/j.bbrc.2013.05.054
436期:1页:47-52
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LOOP-HELIX PROTEINS ; NF-KAPPA-B ; TRANSCRIPTION FACTORS ; LYMPHOCYTE DEVELOPMENT ; IMMUNE-SYSTEM ; RECEPTOR ; INTERLEUKIN-2 ; APOPTOSIS ; SIGNAL ; E2A
英文摘要

Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naive CD4(+) cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-kappa B activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000321682100009
项目编号2011CB946100 ; 30830091 ; 31000393 ; B07001 ; AI56129 ; 7132114
资助机构National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China ; National Institute of Health ; Beijing Natural Science Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54886
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
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Liu, Chen,Jin, Rong,Wang, Hong-Cheng,et al. Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,436(1):47-52.
APA Liu, Chen.,Jin, Rong.,Wang, Hong-Cheng.,Tang, Hui.,Liu, Yuan-Feng.,...&Zhang, Yu.(2013).Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,436(1),47-52.
MLA Liu, Chen,et al."Id1 expression promotes peripheral CD4(+) T cell proliferation and survival upon TCR activation without co-stimulation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436.1(2013):47-52.
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