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Eosinophilic gastroenteritis: Clinical manifestations and morphological characteristics, a retrospective study of 42 patients
Zhang, Li1; Duan, Liping1; Ding, Shigang1; Lu, Jingjing1; Jin, Zhu1; Cui, Rongli1; McNutt, Michael2; Wang, Aiying1
关键词Clinical Endoscopy Eosinophilic Gastroenteritis Histology Radiographic Studies Treatment
刊名SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
2011-09-01
DOI10.3109/00365521.2011.579998
46期:9页:1074-1080
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]OF-THE-LITERATURE ; GASTROINTESTINAL DISORDERS ; HYPEREOSINOPHILIC SYNDROME ; EXPERIENCE
英文摘要

Objective. To evaluate the clinical manifestations, endoscopic, and radiological characteristics, histological features, and treatment of eosinophilic gastroenteritis in adult patients. Methods. The clinical records of 34 patients diagnosed as eosinophilic gastroenteritis and eight patients who had abdominal symptoms and unexplained peripheral eosinophilia but no evidence of tissue eosinophilic infiltration were reviewed and analyzed. Results. Thirteen patients had a history of asthma or allergic rhinitis, while 10 had an allergic history. Peripheral eosinophilia occurred in 83.3% of patients, IgE was elevated in half, and alpha 2-macroglobulin was elevated in 92.8% of patients. The small intestine(82.4%) was the most common site involved. Erythema was the predominate feature seen on endoscopy. Radiographic study generally revealed thickening of the small intestinal wall. Eosinophilia generally involved the lamina propria of mucosa, but any layer of the gut could be affected, even in sites which had normal endoscopic or radiographic appearance. In all, 15.4% (6/39) of patients had Helicobacter pylori infection. Symptom remission within 1 week was found in 80% (20/25) of patients treated with steroids and in 58.8% (10/17) of patients treated with symptomatic treatment. In all, 85.7% (18/21) of patients had their eosinophil counts return to normal within 2 weeks in the steroid treatment group, but none (0/13) in the other group. Conclusion. Eosinophilic gastroenteritis may be more common than previously recognized. Multiple biopsies obtained from the both normal and abnormal appearing areas in the second part of the duodenum are highly recommended. Steroids are effective in relieving symptoms and improving eosinophilia.

语种英语
WOS记录号WOS:000293741900008
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54887
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pathol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Li,Duan, Liping,Ding, Shigang,et al. Eosinophilic gastroenteritis: Clinical manifestations and morphological characteristics, a retrospective study of 42 patients[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,2011,46(9):1074-1080.
APA Zhang, Li.,Duan, Liping.,Ding, Shigang.,Lu, Jingjing.,Jin, Zhu.,...&Wang, Aiying.(2011).Eosinophilic gastroenteritis: Clinical manifestations and morphological characteristics, a retrospective study of 42 patients.SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,46(9),1074-1080.
MLA Zhang, Li,et al."Eosinophilic gastroenteritis: Clinical manifestations and morphological characteristics, a retrospective study of 42 patients".SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 46.9(2011):1074-1080.
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