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Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice
Chen, Tian1; Hu, Jieqiong1; Chen, Chunying2; Pu, Ji1; Cui, Xiaoxing1; Jia, Guang1
关键词Nano Titanium Dioxide Apoe Knockout Mice Inhalation Toxicology Endothelial Dysfunction Lipid Metabolism Atherosclerosis
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2013-05-01
DOI10.1166/jnn.2013.7147
13期:5页:3214-3222
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]C-REACTIVE PROTEIN ; PARTICULATE AIR-POLLUTION ; ACUTE CORONARY SYNDROMES ; HUMAN ENDOTHELIAL-CELLS ; NITRIC-OXIDE ; EARLY ATHEROSCLEROSIS ; HOSPITAL ADMISSIONS ; APOLIPOPROTEIN-E ; IN-VIVO ; DISEASE
英文摘要

Existing studies on the inhalation toxicology of titanium dioxide (TiO2) have focused on possible carcinogenic capacity; however researches on the cardiovascular effect are limited, particularly in terms of susceptible animal models. The present study examined the inhalation toxicology of nano-TiO2 in ApoE knockout mice (ApoE(-/-) mice), an atherosclerosis susceptible animal model. The nano-TiO2 particles used were anatase type and the diameter ranged from 5 to 10 nm. ApoE(-/-) mice were randomly divided into five groups (high dose group, median dose group, low dose group, PBS vehicle control group and the nontreatment control group), each of which were given tracheal instillation of nano-TiO2 at the dose of 100 mu g, 50 mu g and 10 mu g and PBS solution per week respectively, totally for six weeks, while the nontreatment control group received no tracheal instillation. We measured various indicators of inflammation, endothelial dysfunction and lipid metabolism in serum, and determined plaque formation on the aorta. After six weeks of treatment, there was significant difference between the high dose group and PBS control group in terms of C reactive protein (CRP), nitric oxide (NO), endothelial nitric oxide synthases (eNOS), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) in serum. The results also showed ratio of plaque area to luminal area and the ratio of the lipid-rich core area to plaque area in the median and high nano-TiO2 dose group significantly increased respectively in HE stained cross-sections. Our study showed that tracheal instillation of nano-TiO2 particles induced considerable systemic inflammation, endothelial dysfunction and lipid metabolism dysfunction, contributing to the progression of atherosclerosis.

语种英语
WOS记录号WOS:000319953300006
项目编号2011CB933402 ; 30771787
资助机构China Minister of Science and Technology 973 project ; National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54890
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Chen, Tian,Hu, Jieqiong,Chen, Chunying,et al. Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(5):3214-3222.
APA Chen, Tian,Hu, Jieqiong,Chen, Chunying,Pu, Ji,Cui, Xiaoxing,&Jia, Guang.(2013).Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(5),3214-3222.
MLA Chen, Tian,et al."Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.5(2013):3214-3222.
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