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学科主题: 公共卫生
题名:
Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice
作者: Chen, Tian1; Hu, Jieqiong1; Chen, Chunying2; Pu, Ji1; Cui, Xiaoxing1; Jia, Guang1
关键词: Nano Titanium Dioxide ; ApoE Knockout Mice ; Inhalation Toxicology ; Endothelial Dysfunction ; Lipid Metabolism ; Atherosclerosis
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2013-05-01
DOI: 10.1166/jnn.2013.7147
卷: 13, 期:5, 页:3214-3222
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: C-REACTIVE PROTEIN ; PARTICULATE AIR-POLLUTION ; ACUTE CORONARY SYNDROMES ; HUMAN ENDOTHELIAL-CELLS ; NITRIC-OXIDE ; EARLY ATHEROSCLEROSIS ; HOSPITAL ADMISSIONS ; APOLIPOPROTEIN-E ; IN-VIVO ; DISEASE
英文摘要:

Existing studies on the inhalation toxicology of titanium dioxide (TiO2) have focused on possible carcinogenic capacity; however researches on the cardiovascular effect are limited, particularly in terms of susceptible animal models. The present study examined the inhalation toxicology of nano-TiO2 in ApoE knockout mice (ApoE(-/-) mice), an atherosclerosis susceptible animal model. The nano-TiO2 particles used were anatase type and the diameter ranged from 5 to 10 nm. ApoE(-/-) mice were randomly divided into five groups (high dose group, median dose group, low dose group, PBS vehicle control group and the nontreatment control group), each of which were given tracheal instillation of nano-TiO2 at the dose of 100 mu g, 50 mu g and 10 mu g and PBS solution per week respectively, totally for six weeks, while the nontreatment control group received no tracheal instillation. We measured various indicators of inflammation, endothelial dysfunction and lipid metabolism in serum, and determined plaque formation on the aorta. After six weeks of treatment, there was significant difference between the high dose group and PBS control group in terms of C reactive protein (CRP), nitric oxide (NO), endothelial nitric oxide synthases (eNOS), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) in serum. The results also showed ratio of plaque area to luminal area and the ratio of the lipid-rich core area to plaque area in the median and high nano-TiO2 dose group significantly increased respectively in HE stained cross-sections. Our study showed that tracheal instillation of nano-TiO2 particles induced considerable systemic inflammation, endothelial dysfunction and lipid metabolism dysfunction, contributing to the progression of atherosclerosis.

语种: 英语
所属项目编号: 2011CB933402 ; 30771787
项目资助者: China Minister of Science and Technology 973 project ; National Natural Science Foundation of China
WOS记录号: WOS:000319953300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54890
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

Recommended Citation:
Chen, Tian,Hu, Jieqiong,Chen, Chunying,et al. Cardiovascular Effects of Pulmonary Exposure to Titanium Dioxide Nanoparticles in ApoE Knockout Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(5):3214-3222.
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