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Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis
Chen, Min; Yu, Feng; Wang, Suaia; Zou, Wan-Zhong; Zhao, Ming-Hui; Wang, Hai-Yan
刊名JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2007-02-01
DOI10.1681/ASN.2006091021
18期:2页:599-605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]SMALL-VESSEL VASCULITIS ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANCA-ASSOCIATED VASCULITIS ; RENAL VASCULITIS ; MYELOPEROXIDASE ; HISTOLOGY ; KIDNEY
英文摘要

Pauci-immune crescentic glomerulonephritis (CrGN) is one of the most common causes of rapidly progressive glomerulonephritis. The majority of patients with pauci-immune CrGN had circulating antineutrophil cytoplasmic autoantibody (ANCA). However, patients with ANCA-negative pauci-immune CrGN were not investigated fully. This study aimed to analyze the characteristics of this subgroup of patients. Patients whose pauci-immune CrGN was diagnosed from 1997 to 2006 in one center were studied retrospectively. The criteria of pauci-immune was defined as "the intensity of glomerular immunoglobulins staining by direct immunofluorescence assay in renal sections was negative to 1+ staining on a scale of 0 to 4+." Clinical and pathologic characteristics were compared between patients with and without ANCA. Among the 85 patients with pauci-immune CrGN, 28 (32.9%) were ANCA negative. Compared with the 57 ANCA-positive patients, the ANCA-negative patients were much younger (39.7 +/- 17.0 versus 57.6 +/- 14.0 yr; P < 0.001). The level of urinary protein and the prevalence of nephrotic syndrome were significantly higher in ANCA-negative patients than that in ANCA-positive patients (P < 0.01 and P < 0.001, respectively). However, the prevalence of extrarenal involvement was significantly lower in ANCA-negative patients than that in ANCA-positive patients. The renal survival was poorer in ANCA-negative patients than that in ANCA-positive ones (P < 0.05). ANCA-negative pauci-immune CrGN was not rare and might represent an independent disease entity from ANCA-positive vasculitis.

语种英语
WOS记录号WOS:000243917300030
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被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54895
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ First Hosp, Inst Nephrol, Beijing, Peoples R China
2.Peking Univ First Hosp, Div Renal, Beijing 100034, Peoples R China
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GB/T 7714
Chen, Min,Yu, Feng,Wang, Suaia,et al. Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2007,18(2):599-605.
APA Chen, Min,Yu, Feng,Wang, Suaia,Zou, Wan-Zhong,Zhao, Ming-Hui,&Wang, Hai-Yan.(2007).Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,18(2),599-605.
MLA Chen, Min,et al."Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis".JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 18.2(2007):599-605.
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