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学科主题: 临床医学
题名:
Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis
作者: Chen, Min; Yu, Feng; Wang, Suaia; Zou, Wan-Zhong; Zhao, Ming-Hui; Wang, Hai-Yan
刊名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2007-02-01
DOI: 10.1681/ASN.2006091021
卷: 18, 期:2, 页:599-605
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SMALL-VESSEL VASCULITIS ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANCA-ASSOCIATED VASCULITIS ; RENAL VASCULITIS ; MYELOPEROXIDASE ; HISTOLOGY ; KIDNEY
英文摘要:

Pauci-immune crescentic glomerulonephritis (CrGN) is one of the most common causes of rapidly progressive glomerulonephritis. The majority of patients with pauci-immune CrGN had circulating antineutrophil cytoplasmic autoantibody (ANCA). However, patients with ANCA-negative pauci-immune CrGN were not investigated fully. This study aimed to analyze the characteristics of this subgroup of patients. Patients whose pauci-immune CrGN was diagnosed from 1997 to 2006 in one center were studied retrospectively. The criteria of pauci-immune was defined as "the intensity of glomerular immunoglobulins staining by direct immunofluorescence assay in renal sections was negative to 1+ staining on a scale of 0 to 4+." Clinical and pathologic characteristics were compared between patients with and without ANCA. Among the 85 patients with pauci-immune CrGN, 28 (32.9%) were ANCA negative. Compared with the 57 ANCA-positive patients, the ANCA-negative patients were much younger (39.7 +/- 17.0 versus 57.6 +/- 14.0 yr; P < 0.001). The level of urinary protein and the prevalence of nephrotic syndrome were significantly higher in ANCA-negative patients than that in ANCA-positive patients (P < 0.01 and P < 0.001, respectively). However, the prevalence of extrarenal involvement was significantly lower in ANCA-negative patients than that in ANCA-positive patients. The renal survival was poorer in ANCA-negative patients than that in ANCA-positive ones (P < 0.05). ANCA-negative pauci-immune CrGN was not rare and might represent an independent disease entity from ANCA-positive vasculitis.

语种: 英语
WOS记录号: WOS:000243917300030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54895
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Inst Nephrol, Beijing, Peoples R China
2.Peking Univ First Hosp, Div Renal, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Min,Yu, Feng,Wang, Suaia,et al. Antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2007,18(2):599-605.
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