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学科主题: 药学
题名:
Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products
作者: Zhang, He; Guo, Hongzhu; Tian, Yin; Liu, Peng; Li, Na; Zhou, Hanping; Guo, Dean
关键词: 20(S)-protopanaxatriol ; biotransformation ; Mucor spinosus AS 3.3450 ; cytotoxic activity
刊名: PHYTOCHEMISTRY
发表日期: 2007-10-01
DOI: 10.1016/j.phytochem.2007.05.028
卷: 68, 期:20, 页:2523-2530
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: IN-VITRO ; NEOALSOMITRA-INTEGRIFOLIOLA ; DAMMARANE GLYCOSIDES ; CELL-PROLIFERATION ; GINSENG ; GINSENOSIDES ; METASTASIS ; SAPONINS ; LEUKEMIA ; INHIBITION
英文摘要:

Biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus AS 3.3450 gave 10 metabolites (2-10), of which 2-5 were previously known. On the basis of NMR and MS analyses, structures 6-10 were established as 12-oxo-23 beta-hydroxyl-20(S)-protopanaxatriol (6), 20S,24R-epoxy-dammaran-3 beta,6 alpha,25-triol-12-one (7), 29-hydroxyl-20(S)-protopanaxatriol (8a), 12-oxo-11 beta-hydroxyl-20(S)-protopanaxatriol (8b), 28-hydroxyl-20(S)-protopanaxatriol (9) and 12-oxo-20(S)-protopanaxatriol (10). The biotransformation kinetics of 1 has been investigated and a possible biotransformation pathway proposed. The in vitro cytotoxic activities of metabolites against three human cancer cell lines were determined by the MTT method; compounds 8a, 9 and 10 had more potent inhibitory effects against HL-60 cell line than the substrate. (C) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000250950700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54900
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Inst Drug Control, Beijing 100035, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100083, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Nat & Biomimetic Drug, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, He,Guo, Hongzhu,Tian, Yin,et al. Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products[J]. PHYTOCHEMISTRY,2007,68(20):2523-2530.
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