IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010
Wang, Hui1,2; Chen, Minjun1; Xu, Yingchun1; Sun, Hongli1; Yang, Qiwen1; Hu, Yunjian3; Cao, Bin4,5; Chu, Yunzhuo6; Liu, Yong7; Zhang, Rong8; Yu, Yunsong9; Sun, Ziyong10; Zhuo, Chao11; Ni, Yuxing12; Hu, Bijie13; Tan, Thean Yen14; Hsueh, Po-Ren15,16; Wang, Jen-Hsien17; Ko, Wen-Chien18; Chen, Yen-Hsu19; Wahjono, Hendro20
关键词Antibiotic Resistance Surveillance
刊名INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2011-11-01
DOI10.1016/j.ijantimicag.2011.06.015
38期:5页:376-383
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]AMPICILLIN-RESISTANCE GENES ; STREPTOCOCCUS-PNEUMONIAE ; HAEMOPHILUS-INFLUENZAE ; MORAXELLA-CATARRHALIS ; IN-VITRO ; UNITED-STATES ; ANTIBIOTIC-RESISTANCE ; PATTERNS ; EMERGENCE ; MACROLIDE
英文摘要

A multicentre resistance surveillance study [Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS)] investigating the susceptibilities of 2963 clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, meticillin-susceptible Staphylococcus aureus (MSSA) and Streptococcus spp. from Asia against 12 antimicrobial agents was undertaken from 2009 to 2010. Based on the breakpoints for oral penicillin V recommended by the Clinical and Laboratory Standards Institute, the prevalence of penicillin-non-susceptible S. pneumoniae (PNSSP) ranged from 46% to 100%. Azithromycin and clarithromycin exhibited variable resistance rates of 0-88% against S. pneumoniae, 0-57% against MSSA and 0-76.5% against Streptococcus spp. isolates. The prevalence of extended-spectrum beta-lactamase-producing K. pneumoniae varied from 5.1% to 58.5%. beta-Lactamase production rates amongst H. influenzae isolates ranged from 15% to 46.6% and amongst M. catarrhalis isolates from 90% to 100%. Amongst M. catarrhalis isolates, macrolide resistance and cefaclor resistance rates of 5.8% and 1.2%, respectively, were found, mainly in Mainland China. Levofloxacin resistance rates of 0-3.9% with a MIC(90) (minimum inhibitory concentration causing inhibition of 90% of isolates) of 1-2 mg/L and moxifloxacin resistance rates of 0-1.7% with a MIC(90) of 0.125-0.5 mg/L were found amongst PNSSP isolates. Moxifloxacin was very active against Streptococcus spp., H. influenzae and M. catarrhalis isolates, with MIC(90) values of 0.125-0.25, 0.032-0.5 and 0.064-0.125 mg/L, respectively. These results from the CARTIPS study have confirmed some significant regional differences in the antimicrobial susceptibilities of S. pneumoniae, MSSA, K. pneumoniae, H. influenzae and Streptococcus spp. and emphasise the importance of antimicrobial surveillance programmes for guiding empirical therapy and for focusing interventional control of antimicrobial resistance in distinct geographic areas. (C) 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

语种英语
WOS记录号WOS:000296059800003
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54904
专题北京大学第二临床医学院
作者单位1.Beijing Hosp, Minist Hlth, Beijing, Peoples R China
2.China Med Univ, Hosp 2, Shenyang, Peoples R China
3.Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China
4.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China
5.Peking Univ, Dept Clin Lab, Peoples Hosp, Beijing 100871, Peoples R China
6.Capital Med Univ, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
7.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing, Peoples R China
8.China Med Univ, Dept Clin Lab, Hosp 1, Shenyang, Peoples R China
9.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
10.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
11.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China
12.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
13.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
14.Changi Gen Hosp, Div Lab Med, Singapore, Singapore
15.Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 10764, Taiwan
16.Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10764, Taiwan
17.China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan
18.Natl Cheng Kung Univ, Dept Internal Med, Med Coll & Hosp, Tainan 70101, Taiwan
19.Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan
20.Diponegoro Univ, Dr Kariadi Hosp, Dept Clin Microbiol, Fac Med, Semarang, Indonesia
推荐引用方式
GB/T 7714
Wang, Hui,Chen, Minjun,Xu, Yingchun,et al. Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2011,38(5):376-383.
APA Wang, Hui.,Chen, Minjun.,Xu, Yingchun.,Sun, Hongli.,Yang, Qiwen.,...&Wahjono, Hendro.(2011).Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,38(5),376-383.
MLA Wang, Hui,et al."Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 38.5(2011):376-383.
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