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学科主题基础医学
Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue
Fei-Wang2,3; Tian, De-Run1; Tso, Patrick3; Han, Ji-Sheng2
关键词Diet-induced obesity AMPK LKB1 NPY POMC
刊名PEPTIDES
2012-05-01
DOI10.1016/j.peptides.2012.02.003
35期:1页:23-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ACTIVATED PROTEIN-KINASE ; SKELETAL-MUSCLE ; FOOD-INTAKE ; GLUCOSE-TRANSPORT ; UPSTREAM KINASES ; MESSENGER-RNA ; LKB1 ; AMPK ; AICAR ; DEFICIENCY
英文摘要

AMPK not only acts as a sensor of cellular energy status but also plays a critical role in the energy balance of the body. In this study, LKB1-AMPK signaling was investigated in diet-induced obese (DID) and diet resistant (DR) rats. In hypothalamus, DID rats had lower level of LKB1, AMPK alpha and pAMPK alpha than chow-fed or DR rats. Both orexigenic peptide NPY and anorexigenic peptide POMC expression were reduced in hypothalamus of DID rats. i.c.v. injection of AICAR, an activator of AMPK, increased NPY expression but did not alter POMC expression in DID rats. In periphery, LKB1 protein content and pAMPK alpha level were lower in the adipose tissue of DID rats compared to chow-fed and DR rats. Moreover, pAMPK alpha and LKB1 protein levels obtained from epididymal fat pad were inversely correlated with epididymal fat mass. LKB1 protein content and pAMPK alpha in skeletal muscle of DID rats were not different from those in the muscles of chow-fed and DR rats. In summary, DID rats, but not DR rats, have impaired LKB1-AMPK signaling in hypothalamus and adipose tissue, suggesting the disturbed energy balance observed in DIO rats is related with abnormalities of AMPK signaling in a tissue specific manner. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000303963800004
项目编号07JCZDJC08100 ; 30870791
资助机构Natural Science Foundation of Tianjin ; National Natural Science Foundation of China ; Ministry of Education
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54908
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
3.Univ Cincinnati, Dept Pathol, Genome Res Inst, Cincinnati, OH USA
推荐引用方式
GB/T 7714
Fei-Wang,Tian, De-Run,Tso, Patrick,et al. Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue[J]. PEPTIDES,2012,35(1):23-30.
APA Fei-Wang,Tian, De-Run,Tso, Patrick,&Han, Ji-Sheng.(2012).Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue.PEPTIDES,35(1),23-30.
MLA Fei-Wang,et al."Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue".PEPTIDES 35.1(2012):23-30.
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