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学科主题: 临床医学
题名:
Parental History of Premature Cardiovascular Disease, Estimated GFR, and Rate of Estimated GFR Decline: Results From the Aerobics Center Longitudinal Study
作者: Huang, Xiaoyan1,2,3; Sui, Xuemei4; Ruiz, Jonatan R.5; Hirth, Victor6; Ortega, Francisco B.5; Blair, Steven N.4,7; Carrero, Juan J.2,3,8
关键词: Cardiovascular disease (CVD) ; chronic kidney disease (CKD) ; glomerular filtration rate (GFR) ; renal function ; kidney disease progression ; heart ; kidney ; random-coefficient model ; parental history ; risk factor ; Aerobics Center Longitudinal Study (ACLS)
刊名: AMERICAN JOURNAL OF KIDNEY DISEASES
发表日期: 2015-05-01
DOI: 10.1053/j.ajkd.2014.11.021
卷: 65, 期:5, 页:692-700
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; CORONARY-HEART-DISEASE ; STAGE RENAL-DISEASE ; GLOMERULAR-FILTRATION-RATE ; FAMILY-HISTORY ; ALL-CAUSE ; BLOOD-PRESSURE ; RISK-FACTORS ; CARDIORESPIRATORY FITNESS ; MYOCARDIAL-INFARCTION
英文摘要:

Background: Despite cardiovascular disease (CVD) and chronic kidney disease sharing similar causes and interplay, it is unknown if a broader relationship between these diseases exists across generations. We investigated the association between parental CVD history and estimated glomerular filtration rate (eGFR) in the community.

Study Design: Cross-sectional and longitudinal analyses.

Setting & Participants: 13,241 community-based adults with serum creatinine measurement and follow-up visits (from 1-8 visits similar to 2 years apart) from the Aerobics Center Longitudinal Study.

Predictors: Premature parental CVD history (before age 50 years).

Outcomes: eGFR, decreased eGFR (<60 mL/min/1.73 m(2)), and rate of eGFR decline.

Measurements: Information for parental history was collected by protocol-standardized questionnaires. eGFR was assessed with serum creatinine.

Results: 3,339 (25.2%) participants reported a history of parental CVD. Individuals with parental CVD had significantly lower eGFRs compared with those without parental CVD (69.4 +/- 12.9 vs 74.8 +/- 14.2 mL/min/1.73 m(2); P < 0.001). After multivariable adjustment, parental CVD was associated independently with higher odds of having decreased eGFR (adjusted OR, 1.68; 95% CI, 1.52-1.86). Random-coefficient models showed that individuals with parental CVD had a faster decline in eGFR compared with those without parental CVD (sex-and ethnicity-adjusted annual change of -0.47 vs -0.41 mL/min/1.73 m(2); P = 0.06).

Limitations: similar to 70% of participants did not attend a second examination.

Conclusions: Parental history of CVD was associated with lower baseline eGFR, higher odds of decreased eGFR, and a nominally faster rate of eGFR decline in the offspring. Such findings may imply previously unrecognized cross-generational links between both diseases and be of support in community screening programs. (C) 2015 by the National Kidney Foundation, Inc.

语种: 英语
所属项目编号: 81402737 ; AG06945 ; HL62508 ; DK088195 ; RYC-2010-05957 ; RYC-2011-09011
项目资助者: National Science Foundation ; Swedish Research Council ; National Institutes of Health ; Spanish Ministry of Economy and Competitiveness
WOS记录号: WOS:000356723300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54909
Appears in Collections:北京大学深圳医院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Div Nephrol, CN-518036 Shenzhen, Peoples R China
2.Karolinska Inst, Div Renal Med, Stockholm, Sweden
3.Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
4.Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA
5.Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, PROFITH Res Grp PROmoting FITness & Hlth Phys Act, Granada, Spain
6.Univ S Carolina, Sch Med, Div Geriatr, Columbia, SC 29208 USA
7.Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
8.Karolinska Inst, Ctr Mol Med, Stockholm, Sweden

Recommended Citation:
Huang, Xiaoyan,Sui, Xuemei,Ruiz, Jonatan R.,et al. Parental History of Premature Cardiovascular Disease, Estimated GFR, and Rate of Estimated GFR Decline: Results From the Aerobics Center Longitudinal Study[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2015,65(5):692-700.
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