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学科主题: 基础医学
题名:
Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2)
作者: Duan, XZ; Zhuang, H; Wang, M; Li, HW; Liu, JC; Wang, FS
关键词: chronic hepatitis B ; dendritic cells ; liver cirrhosis ; subsets
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2005-02-01
DOI: 10.1111/j.1400-1746.2004.03529.x
卷: 20, 期:2, 页:234-242
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTERFERON-PRODUCING CELLS ; PERIPHERAL-BLOOD ; HEPATOCELLULAR-CARCINOMA ; ADAPTIVE IMMUNITY ; I INTERFERON ; LIVER ; REDUCTION ; INNATE
英文摘要:

Background and Aim: To investigate the frequencies, numbers and function of circulating dendritic cell (DC) subsets in patients with hepatitis B virus (HBV) infection, we assayed the circulating precursor DC subsets (including pDC1 and pDC2) and their ability in patients at various stages of HBV infection in vitro.

Methods: Circulating pDC1 and pDC2 frequencies in peripheral blood mononuclear cells (PBMC) were analyzed by flow cytometric analysis. Costimulatory molecule expression and allostimulatory mixed lymphocyte reaction (AMLR) of DC1, cultured from PBMC in vitro, were detected in patients with chronic hepatitis B (CHB). On behalf of pDC2, interferon (IFN)-alpha production of PBMC was determined by the ELISA method in HBV-infected patients.

Results: The number of circulating pDC1 decreased only in patients with liver cirrhosis (LC) compared with that in normal controls. However, pDC2 numbers decreased in both CHB and LC patients. DC I from CHB patients showed lower expression of costimulatory molecules CD80, CD86 and impaired allostimulatory mixed lymphocyte reaction (AMLR) compared with those in normal controls. The ability of PBMC to secrete IFN-alpha. also decreased significantly in patients with chronic HBV infection.

Conclusions: Our results suggest that patients with chronic HBV infection have a significantly lower expression of costimulatory molecules and impaired AMLR of pDC1, as well as decreased number and impaired function of circulating pDC2, which may be partially related to HBV disease progression in these patients. (C) 2004 Blackwell Publishing Asia Pry Ltd.

语种: 英语
WOS记录号: WOS:000227609900011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54915
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Beijing 302 Hosp PLA, Beijing Inst Infect Dis, Res Ctr Biol Therapy, Beijing 100039, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China

Recommended Citation:
Duan, XZ,Zhuang, H,Wang, M,et al. Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2)[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2005,20(2):234-242.
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