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学科主题临床医学
Telomere Shortening Is Associated with Genetic Anticipation in Chinese Von Hippel-Lindau Disease Families
Ning, Xiang-hui1,3,4; Zhang, Ning5; Li, Teng1,3,4; Wu, Peng-jie1,3,4; Wang, Xi1,3,4; Li, Xue-ying2; Peng, Shuang-he1,3,4; Wang, Jiang-yi1,3,4; Chen, Jin-chao1,3,4; Gong, Kan1,3,4
刊名CANCER RESEARCH
2014-07-15
DOI10.1158/0008-5472.CAN-14-0024
74期:14页:3802-3809
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Program for New Century Excellent Talents in Universities ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in Universities ; National Natural Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR GENE ; AT-ONSET ANTICIPATION ; DYSKERATOSIS-CONGENITA ; LYNCH SYNDROME ; VHL GENE ; AGE ; CANCER ; DNA ; MUTATIONS ; IDENTIFICATION
英文摘要

Von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome. A phenomenon known as genetic anticipation has been documented in some hereditary cancer syndromes, where it was proved to relate to telomere shortening. Because studies of this phenomenon in VHL disease have been relatively scarce, we investigated anticipation in 18 Chinese VHL disease families. We recruited 34 parent-child patient pairs (57 patients) from 18 families with VHL disease. Onset age was defined as the age when any symptom or sign of VHL disease first appeared. Anticipation of onset age was analyzed by paired t test and the other two special tests (HV and RY2). Relative telomere length of peripheral leukocytes was measured in 29 patients and 325 healthy controls. Onset age was younger in child than in parent in 31 of the 34 parent-child pairs. Patients in the first generation had older onset age with longer age-adjusted relative telomere length, and those in the next generation had younger onset age with shorter age-adjusted relative telomere length (P < 0.001) in the 10 parent-child pairs from eight families with VHL disease. In addition, relative telomere length was shorter in the 29 patients with VHL disease than in the normal controls (P = 0.003). The anticipation may relate to the shortening of telomere length in patients with VHL in successive generations. These findings indicate that anticipation is present in families with VHL disease and may be helpful for genetic counseling for families with VHL disease families and for further understanding the pathogenesis of VHL disease. (C) 2014 AACR.

语种英语
所属项目编号NCET-10-0190 ; 30872560 ; 81172418
资助者Program for New Century Excellent Talents in Universities ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in Universities ; National Natural Science Foundation of China
WOS记录号WOS:000338875000015
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54919
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Natl Urol Canc Ctr, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Med Stat, Beijing 100034, Peoples R China
5.Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Urol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ning, Xiang-hui,Zhang, Ning,Li, Teng,et al. Telomere Shortening Is Associated with Genetic Anticipation in Chinese Von Hippel-Lindau Disease Families[J]. CANCER RESEARCH,2014,74(14):3802-3809.
APA Ning, Xiang-hui.,Zhang, Ning.,Li, Teng.,Wu, Peng-jie.,Wang, Xi.,...&Gong, Kan.(2014).Telomere Shortening Is Associated with Genetic Anticipation in Chinese Von Hippel-Lindau Disease Families.CANCER RESEARCH,74(14),3802-3809.
MLA Ning, Xiang-hui,et al."Telomere Shortening Is Associated with Genetic Anticipation in Chinese Von Hippel-Lindau Disease Families".CANCER RESEARCH 74.14(2014):3802-3809.
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