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学科主题精神卫生
Effectiveness and Tolerability of Aripiprazole in Children and Adolescents with Tourette′s Disorder: A Pilot Study in China
Cui, Yong-hua1; Zheng, Yi1; Yang, Yun-ping1; Liu, Jing2; Li, Jun3
刊名JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
2010-08-01
DOI10.1089/cap.2009.0125
20期:4页:291-298
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]TIC-SEVERITY-SCALE ; ATYPICAL ANTIPSYCHOTIC-DRUG ; OPEN-LABEL ; ACUTE DYSTONIA ; CASE SERIES ; RISPERIDONE ; OLANZAPINE ; ZIPRASIDONE ; TRIAL ; YOUTH
英文摘要

Objective: The primary aim of the study was to evaluate the effectiveness and tolerability of aripiprazole on motor and vocal tics in children and adolescents with Tourette′s disorder (TD). The secondary aim was to assess the response of TD-associated behaviors to aripiprazole exposure.

Methods: This was an 8-week, open-label trial with flexible dosing strategy of aripiprazole in children and adolescaents with TD. A total of 72 patients, aged 6-18 years, participated in the 8-week trial. The Yale Global Tic Severity Scale (YGTSS), the Clinical Global Impressions-Tics (CGI-Tics), and the Child Behavior Checklist (CBCL) were compared at the baseline, weeks 2 and 4, and end point. The side effects of aripiprazole, electrocardiogram (ECG), and body mass index (BMI) were evaluated.

Results: Over the 8-week trial, aripiprazole administration was associated with a significant decrease in total tic severity as measured by the YGTSS (50.3% reduction by week 8). The mean scores of motor tic in the YGTSS were 17.42 +/- 4.83, 12.93 +/- 3.76, 8.39 +/- 3.70, and 6.75 +/- 3.95 at baseline, weeks 2 and 4, and end point. A significant decrease in the scores was observed in week 2 compared to the baseline, and the scores continued to decrease for the remainder of the study period (degrees of freedom [df] 3, F 96.02, p 0.000). The mean phonic tic scores were 12.71 +/- 4.60, 8.53 +/- 3.26, 6.10 +/- 2.50, and 3.63 +/- 2.20 at baseline, weeks 2 and 4, and end point, respectively. A significant change was observed during week 2 compared to the baseline, and this change continued for the rest of the study period (df = 3, F = 95.16, p = 0.000). Significant improvement was also observed according to the CGI- Tics severity. The mean CGI- Tics severity score was 4.77 +/- 1.69 at baseline and decreased to 2.20 +/- 1.39 at end point (t = 10.70, p = 0.000). A significant reduction of behavior symptoms was noticed according to the CBCL and its subscales between baseline and end point. The majority of subjects tolerated aripiprazole well. The extrapyramidal symptoms (EPS) during this study were negligible. In all 21 (29.2%) of the 72 participants complained of nausea and 19 (26.4%) of them reported sedation. There was no significant difference of BMI between the two phases (df = 64, t = -0.94, p = 0.352). There were no significant changes in laboratory results. ECG monitoring revealed no significant impact on cardiac conduction by aripiprazol.

Conclusion: In this preminary open- label trial, aripiprazole showed effectiveness in treating tic symptoms without causing significant weight gain or other serious side effects. Aripiprazole could be an option for TD cases that do not respond to conventional therapies. Further controlled, double- blind studies are warranted.

语种英语
WOS记录号WOS:000281435700007
资助机构Beijing city health administration
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54924
专题北京大学精神卫生研究所
作者单位1.Beijing Univ, Hosp 6, Beijing 100871, Peoples R China
2.Beijing Normal Univ, Beijing 100875, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China
推荐引用方式
GB/T 7714
Cui, Yong-hua,Zheng, Yi,Yang, Yun-ping,et al. Effectiveness and Tolerability of Aripiprazole in Children and Adolescents with Tourette′s Disorder: A Pilot Study in China[J]. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY,2010,20(4):291-298.
APA Cui, Yong-hua,Zheng, Yi,Yang, Yun-ping,Liu, Jing,&Li, Jun.(2010).Effectiveness and Tolerability of Aripiprazole in Children and Adolescents with Tourette′s Disorder: A Pilot Study in China.JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY,20(4),291-298.
MLA Cui, Yong-hua,et al."Effectiveness and Tolerability of Aripiprazole in Children and Adolescents with Tourette′s Disorder: A Pilot Study in China".JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY 20.4(2010):291-298.
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