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Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats
Ma, Xiaoyan2; Zhang, Hui2; Wang, Ke1; Yang, Liyuan1; Qin, Lihua1; Bai, Wenpei2; Guan, Youfei3; Jia, Jing4; Kang, Jihong3; Zhou, Changman1
关键词Black Cohosh Cimicifuga Racemosa Abnormal Thermoregulation Central Body Temperature Rats
刊名JOURNAL OF ETHNOPHARMACOLOGY
2011-10-31
DOI10.1016/j.jep.2011.08.076
138期:1页:156-161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
资助者National Natural Science Funds ; Gynecology Department of the First Hospital of Peking University ; National Natural Science Funds ; Gynecology Department of the First Hospital of Peking University
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]THERMOREGULATORY DYSFUNCTION ; MENOPAUSAL SYMPTOMS ; DOUBLE-BLIND ; HOT FLASHES ; TAIL-SKIN ; PHYSIOLOGY ; TIBOLONE ; WOMEN
英文摘要

Ethnopharmacological relevance: Black cohosh (Cimicifuga racemosa) is widely used in menopause symptoms strategy.

Aim of the study: The aim of this study was to examine the effect of isopropanolic black cohosh extract (iCR) on the central body temperature (CBT) of ovariectomized rats (OVX) and elaborate its possible effects in alleviating menopause related hot flushes.

Materials and methods: 64 female Sprague-Dawley rats, weighing 230 +/- 10g and aged 6-8 weeks, were divided into four groups: ovariectomy (OVX), sham, ovariectomy plus estradiol valerate (OVX + E), and ovariectomy plus iCR (OVX+ICR). The sham group underwent a sham surgery without ovariectomies, while the other three groups underwent bilateral ovariectomies under sterile conditions and a temperature implant was embedded in the abdominal cavity of all four groups. After 2-week recovery period, the temperature of all animals was monitored for 6 weeks.

Results: CBT of four groups maintained a normal circadian rhythm, with a low day CBT and a high night CBT. CBTs of the sham group were lower than that of the other three groups. The day CBTs of the (OVX + E) group and (OVX + ICR) group were lower than that of the OVX group from day 2 and day 22 respectively. For the difference between day and night CBT, the sham group was smallest, while (OVX + E) and (OVX + ICR) groups were higher than that of OVX group. The amplitude of day and night CBT, CBT fluctuation frequency at 5 min intervals, were higher for the OVX group than the sham group; the amplitude of day and night CBT of (OVX + E) group and the amplitude of night CBT of (OVX + ICR) group were higher than those of OVX group; while the amplitude of day CBT of (OVX+ICR) group was lower than that of OVX group; CBT fluctuation frequency at 5 min intervals was higher for the (OVX + E) and (OVX + ICR) groups than the OVX group.

Conclusions: Ovariectomized rats had abnormal thermoregulation, demonstrating an increase in day and night CBT, greater difference between day and night CBT, higher amplitude of day and night CBT, and more CBT fluctuation frequency. For the herbal extract iCR, the onset of affecting abnormal thermoregulation took longer than that of estradiol valerate. ICR had a significant effect on day CBT but was only little effective on night CBT of ovariectomized rats. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号81070462
资助者National Natural Science Funds ; Gynecology Department of the First Hospital of Peking University ; National Natural Science Funds ; Gynecology Department of the First Hospital of Peking University
WOS记录号WOS:000297896500020
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54927
专题北京大学第一临床医学院_妇产科
作者单位1.Gen Hosp Armed Police, Dept Stomatol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Gynecol, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiaoyan,Zhang, Hui,Wang, Ke,et al. Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2011,138(1):156-161.
APA Ma, Xiaoyan.,Zhang, Hui.,Wang, Ke.,Yang, Liyuan.,Qin, Lihua.,...&Zhou, Changman.(2011).Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats.JOURNAL OF ETHNOPHARMACOLOGY,138(1),156-161.
MLA Ma, Xiaoyan,et al."Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats".JOURNAL OF ETHNOPHARMACOLOGY 138.1(2011):156-161.
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