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学科主题: 药学
题名:
Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships
作者: Liu, Peng; Guo, Hongzhu; Wang, Weixing; Zhang, Jie; Li, Na; Han, Jian; Zhou, Jianping; Hu, Yuchi; Zhang, Tong; Liu, Zhenming; Guo, Dean
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2007-04-01
DOI: 10.1021/np060439q
卷: 70, 期:4, 页:533-537
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: ACID-B ; ACETATES
英文摘要:

Four new diterpenoids, 11S-deacetylpseudolaric acid A (2), deacetylpseudolaric acid A O-beta-D-glucopyranoside (3), deacetylpseudolaric acid A 2,3-dihydroxypropyl ester (4), and deacetylpseudolaric acid B 2,3-dihydroxypropyl ester (5), and nine known diterpenoids were isolated from the bark of Pseudolarix kaempferi. Their structures were determined on the basis of chemical and spectroscopic analyses. In addition, their in vitro cytotoxic activities against three human cancer cell lines and their structure-activity relationships were evaluated.

语种: 英语
WOS记录号: WOS:000246007200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54934
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Inst Drug Control, Beijing 100035, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100083, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Peng,Guo, Hongzhu,Wang, Weixing,et al. Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(4):533-537.
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