IR@PKUHSC  > 北京大学药学院
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Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile
Sun, Jiang-Hao1; Yang, Min2; Ma, Xiao-Chi1; Kang, Jie1; Han, Jian1; Guo, De-An1,2
关键词Biotransformation Cryptotanshinone Cunninghamella Elegans Diterpenes Salvia Miltiorrhiza
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2009
DOI10.1080/10286020902877754
11期:6页:482-489
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者Program for Changjiang Scholars and Innovative Team in University ; Program for Changjiang Scholars and Innovative Team in University
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHIC DETERMINATION ; IN-VITRO CYTOTOXICITY ; SALVIA-MILTIORRHIZA ; PENICILLIUM-JANTHINELLUM ; ACTIVE METABOLITE ; TANSHINONE IIA ; PLASMA ; ROOTS ; URINE
英文摘要

Cryptotanshinone (1) is one of the major bioactive constituents in Salvia miltiorrhiza Bunge. Preparative-scale biotransformation of cryptotanshinone by Cunninghamella elegans (AS 3.2082) produced three new products, which were identified as (3R, 15R)-3-hydroxycryptotanshinone (2), (3S, 15R)-3-hydroxycryptotanshinone (3), and (4S, 15R)-18-hydroxycryptotanshinone (4), respectively. The structural elucidation was based primarily on 1D and 2D NMR and HR-ESI-MS analyses. The absolute configuration of these three products was confirmed by comparison of their circular dichroism spectra with those of the known compounds. These biotransformed metabolites were used as for the comparison of in vivo metabolites in rat bile sample after intravenous administration and they are identical to three of the minor hydroxylated metabolites in vivo, which suggested that microbial biotransformation model was a useful and feasible approach for the preparation of mammalian metabolites in trace.

语种英语
所属项目编号985-2-063-112
资助者Program for Changjiang Scholars and Innovative Team in University ; Program for Changjiang Scholars and Innovative Team in University
WOS记录号WOS:000268665700002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54935
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
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GB/T 7714
Sun, Jiang-Hao,Yang, Min,Ma, Xiao-Chi,et al. Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(6):482-489.
APA Sun, Jiang-Hao,Yang, Min,Ma, Xiao-Chi,Kang, Jie,Han, Jian,&Guo, De-An.(2009).Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(6),482-489.
MLA Sun, Jiang-Hao,et al."Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.6(2009):482-489.
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