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学科主题: 临床医学
题名:
Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis
作者: Zhang, Yuanjin; Wang, Liping; Fu, Yu; Song, Hongsong; Zhao, Haiyan; Deng, Min; Zhang, Jun; Fan, Dongsheng
关键词: Amyotrophic lateral sclerosis ; granulocyte colony stimulating factor ; ALS functional rating scale ; compound muscle action potential amplitude
刊名: AMYOTROPHIC LATERAL SCLEROSIS
发表日期: 2009
DOI: 10.3109/17482960802588059
卷: 10, 期:5-6, 页:430-431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DONORS
英文摘要:

We investigated the safety and efficacy of the granulocyte colony stimulating factor (G-CSF) in 13 patients with amyotrophic lateral sclerosis (ALS). Five-day administration of 2 mg/kg once a day was followed by a six-month observation period. The primary and secondary endpoints were the changes of ALS functional rating scale (ALSFRS) and the compound muscle action potential ( CMAP) amplitude, respectively. We found that the declines of ALSFRS and CMAP amplitude after G-CSF administration were significantly less than those measured prior to the treatment. The results suggest G-CSF is safe in ALS patients, and may affect the rate of motor decline.

语种: 英语
WOS记录号: WOS:000272294000025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54937
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Dept Neurol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Yuanjin,Wang, Liping,Fu, Yu,et al. Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis[J]. AMYOTROPHIC LATERAL SCLEROSIS,2009,10(5-6):430-431.
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