IR@PKUHSC  > 北京大学第三临床医学院  > 神经内科
学科主题临床医学
Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis
Zhang, Yuanjin; Wang, Liping; Fu, Yu; Song, Hongsong; Zhao, Haiyan; Deng, Min; Zhang, Jun; Fan, Dongsheng
关键词Amyotrophic Lateral Sclerosis Granulocyte Colony Stimulating Factor Als Functional Rating Scale Compound Muscle Action Potential Amplitude
刊名AMYOTROPHIC LATERAL SCLEROSIS
2009
DOI10.3109/17482960802588059
10期:5-6页:430-431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DONORS
英文摘要

We investigated the safety and efficacy of the granulocyte colony stimulating factor (G-CSF) in 13 patients with amyotrophic lateral sclerosis (ALS). Five-day administration of 2 mg/kg once a day was followed by a six-month observation period. The primary and secondary endpoints were the changes of ALS functional rating scale (ALSFRS) and the compound muscle action potential ( CMAP) amplitude, respectively. We found that the declines of ALSFRS and CMAP amplitude after G-CSF administration were significantly less than those measured prior to the treatment. The results suggest G-CSF is safe in ALS patients, and may affect the rate of motor decline.

语种英语
WOS记录号WOS:000272294000025
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54937
专题北京大学第三临床医学院_神经内科
作者单位Peking Univ, Dept Neurol, Hosp 3, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Yuanjin,Wang, Liping,Fu, Yu,et al. Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis[J]. AMYOTROPHIC LATERAL SCLEROSIS,2009,10(5-6):430-431.
APA Zhang, Yuanjin.,Wang, Liping.,Fu, Yu.,Song, Hongsong.,Zhao, Haiyan.,...&Fan, Dongsheng.(2009).Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis.AMYOTROPHIC LATERAL SCLEROSIS,10(5-6),430-431.
MLA Zhang, Yuanjin,et al."Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis".AMYOTROPHIC LATERAL SCLEROSIS 10.5-6(2009):430-431.
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