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The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization
Gao, Yang1,2; Peng, Shuxian1,2; Wen, Quan1,2; Zheng, Chunming1,2; Lin, Jue1,2; Tan, Yalun1,2; Ma, Yan1,2; Luo, Yixiao3; Xue, Yanxue3; Wu, Ping3; Ding, Zengbo3; Lu, Lin3; Li, Yanqin1,2
关键词Amygdala Locomotor Sensitization Mtorc1 Nicotine Rapamycin
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
2014-11-01
DOI10.1017/S1461145714000650
17期:11页:1881-1894
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]INDUCED PLACE PREFERENCE ; NUCLEUS-ACCUMBENS ; SIGNALING PATHWAY ; ACETYLCHOLINE-RECEPTORS ; HORSERADISH-PEROXIDASE ; NEURONAL DEVELOPMENT ; AXONAL-TRANSPORT ; STIMULANT-DRUGS ; FEAR MEMORY ; RAT-BRAIN
英文摘要

Repeated exposure to nicotine increases psychomotor activity. Long-lasting neural plasticity changes that contribute to the nicotine-induced development of locomotor sensitization have been identified. The mammalian target of rapamycin complex 1 (mTORC1) signalling pathway is involved in regulating the neuroplasticity of the central nervous system. In this study, we examined the role of mTORC1 in the amygdala in nicotine-induced locomotor sensitization. Rapamycin, an inhibitor of mTORC1, was infused into the basolateral amygdala (BLA) and central amygdala (CeA) or systemically administered to investigate the role of the mTORC1 in the development and expression of nicotine-induced locomotor sensitization. We found that locomotor activity progressively increased during the initiation of nicotine-induced locomotor sensitization and the expression of nicotine sensitization was induced by nicotine challenge injection (0.35 mg/kg s.c.) after five days of withdrawal. The initiation of nicotine-induced locomotor sensitization was accompanied by the increased phosphorylated level of mTORC1 downstream target proteins including p-p70s6k and p-4EBP in the BLA, but not CeA. Intra-BLA infusion or systemic administration of rapamycin blocked locomotor activity. Increased p-p70s6k and p-4EBP were also observed in the expression of nicotine sensitization, which was demonstrated to be inhibited by systemic rapamycin administration. Our findings indicated that mTORC1 activity in the BLA, but not the CeA, mediated the initiation and expression of nicotine-induced locomotor sensitization, and may become a potential target for the treatment of nicotine addiction.

语种英语
WOS记录号WOS:000345005400014
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54938
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
2.Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Gao, Yang,Peng, Shuxian,Wen, Quan,et al. The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2014,17(11):1881-1894.
APA Gao, Yang.,Peng, Shuxian.,Wen, Quan.,Zheng, Chunming.,Lin, Jue.,...&Li, Yanqin.(2014).The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,17(11),1881-1894.
MLA Gao, Yang,et al."The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17.11(2014):1881-1894.
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