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学科主题临床医学
Effects of long-term application of metoprolol and propranolol in a rat model of smoking
Zhou, Yujiao1,2,3; Xu, Ming1,2,3; Zhang, Yuan1,2,3; Guo, Yang4; Zhang, Youyi1,2,3; He, Bei1,2,3
关键词-adrenoceptor Airway Inflammation Beta-blocker Lung Function Mucin Smoking Rat Model
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2014-09-01
DOI10.1111/1440-1681.12261
41期:9页:708-715
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; CARDIOSELECTIVE BETA-BLOCKERS ; MURINE ASTHMA MODEL ; COPD ; BETA(2)-ADRENOCEPTOR ; LUNG ; EXACERBATIONS ; ADRENOCEPTORS ; INFLAMMATION ; METAANALYSIS
英文摘要

Beta-blockers, especially selective (1)-adrenoceptor antagonists, are often used to treat cardiovascular disease, even when complicated by chronic obstructive pulmonary disease. The association of beta-blocker selectivity and treatment effects is disputed, and the curative effects and side-effects of various antagonists may differ. Herein we investigated the effects of 1months treatment with the selective (1)-adrenoceptor antagonist metoprolol and the non-selective -adrenoceptor antagonist propranolol on pulmonary function and pathology in a 4-month rat model of passive cigarette smoke exposure and explored potential mechanisms of action. Lung function and general pathological changes were evaluated after 4months exposure to cigarette smoke, with metoprolol and propranolol treatment (50 and 25mg/kg per day, respectively; intragastrically) during the last month. Cytokine and mucin levels in bronchoalveolar lavage fluid (BALF) were determined by ELISA, whereas (1)- and (2)-adrenoceptor expression in the lungs was evaluated by immunohistochemistry and western blot analysis. Chronic treatment with metoprolol and propranolol did not exacerbate peak expiratory flow or intra-airway pressure in rats exposed to cigarette smoke. Propranolol significantly attenuated inflammatory cell infiltration, cytokine levels (tumour necrosis factor- and interleukin-8) in BALF or mucus secretion, whereas metoprolol reduced only smooth muscle proliferation. Moreover, propranolol treatment was associated (albeit not significantly) with restoring (2)-adrenoceptor expression in airway epithelia. Propranolol had a more beneficial effect on cigarette smoking-induced lung damage than metoprolol in a smoking rat model that may be associated with restoration of endogenous (2)-adrenoceptor density in the airway epithelial cells.

语种英语
WOS记录号WOS:000344348100014
项目编号81270097 ; 7112745 ; 20090001110093
资助机构National Natural Science Foundation of China ; PhD Programs Foundation of the Ministry of Education of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54939
专题北京大学第三临床医学院_呼吸科
作者单位1.Changji Renmin Hosp, Dept Resp Med, Changji, Xinjiang, Peoples R China
2.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
4.Minist Hlth, Beijing Key Lab Cardiovasc Receptors Res, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Yujiao,Xu, Ming,Zhang, Yuan,et al. Effects of long-term application of metoprolol and propranolol in a rat model of smoking[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2014,41(9):708-715.
APA Zhou, Yujiao,Xu, Ming,Zhang, Yuan,Guo, Yang,Zhang, Youyi,&He, Bei.(2014).Effects of long-term application of metoprolol and propranolol in a rat model of smoking.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,41(9),708-715.
MLA Zhou, Yujiao,et al."Effects of long-term application of metoprolol and propranolol in a rat model of smoking".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41.9(2014):708-715.
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