IR@PKUHSC  > 北京大学第三临床医学院  > 放射科
学科主题临床医学
Maximizing the Relaxivity of Gd-Complex by Synergistic Effect of HSA and Carboxylfullerene
Zhen, Mingming1,2; Zheng, Junpeng1,2; Ye, Lei1,2; Li, Shumu1,2; Jin, Chan4; Li, Kai3; Qiu, Dong1; Han, Hongbin3; Shu, Chunying1; Yang, Yongji4; Wang, Chunru1
关键词Macromolecular Mri Contrast Agents Contrast Enhancement Carboxylfullerene Theranostics Photosensitizer Intracellular Imaging
刊名ACS APPLIED MATERIALS & INTERFACES
2012-07-01
DOI10.1021/am300817z
4期:7页:3724-3729
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
资助者973 Program ; National Natural Science Foundation of China ; NSAF ; SRF for ROCS, SEM ; 973 Program ; National Natural Science Foundation of China ; NSAF ; SRF for ROCS, SEM
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]MRI CONTRAST AGENTS ; FAST WATER EXCHANGE ; HUMAN SERUM-ALBUMIN ; PHOTODYNAMIC THERAPY ; RATIONAL DESIGN ; III COMPLEXES ; FULLERENE ; DENDRIMERS ; DELIVERY ; RATES
英文摘要

Macromolecular magnetic resonance imaging (MRI) contrast agent Gd-DTPA-HSA (DTPA, diethylene triamine pentacetate acid; HSA, human serum albumin) as a model has been successfully conjugated with trimalonic acid modified C-60 for contrast enhancement at clinically used magnetic field strength. The Gd-DTPA-HSA-C-60 conjugate exhibit maximal relaxivity (r(1) = 86 mM(-1) s(-1) at 0.5 T, 300 K) reported so far, which is much superior to that of the control Gd-DTPA-HSA (r(1) = 38 mM(-1) s(-1)) under the same condition and comparable to the theoretical maximum (r(1) = 80-120 mM(-1) s(-1), at 20 MHz and 298 K), indicating the synergistic effect of HSA and carboxylfullerene on the increased contrast enhancement. TEM characterization reveals that both Gd-DTPA-HSA-C-60 and Gd-DTPA-HSA can penetrate the cells via endocytosis and trans membrane, respectively, suggesting the potential to sensitively image the events at the cellular and subcellular levels. In addition, the fusion of fullerene with Gd-DTPA-HSA will further endow the resulting complex with photodynamic therapy (PDT) property and thus combine the modalities of therapy (PDT) and diagnostic imaging (MRI) into one entity. More importantly, the payloaded Gd-DTPA may substitute for other more stable Gd-DOTA and HSA as a theranostic package can further work as a drug delivery carrier and effectively control drug release through proteolysis.

语种英语
所属项目编号2011CB302100 ; 21121063 ; 51072200 ; 31170963 ; 11076027
资助者973 Program ; National Natural Science Foundation of China ; NSAF ; SRF for ROCS, SEM ; 973 Program ; National Natural Science Foundation of China ; NSAF ; SRF for ROCS, SEM
WOS记录号WOS:000306722400054
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54942
Collection北京大学第三临床医学院_放射科
作者单位1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
4.Second Mil Med Univ, Inst Biophys, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Zhen, Mingming,Zheng, Junpeng,Ye, Lei,et al. Maximizing the Relaxivity of Gd-Complex by Synergistic Effect of HSA and Carboxylfullerene[J]. ACS APPLIED MATERIALS & INTERFACES,2012,4(7):3724-3729.
APA Zhen, Mingming.,Zheng, Junpeng.,Ye, Lei.,Li, Shumu.,Jin, Chan.,...&Wang, Chunru.(2012).Maximizing the Relaxivity of Gd-Complex by Synergistic Effect of HSA and Carboxylfullerene.ACS APPLIED MATERIALS & INTERFACES,4(7),3724-3729.
MLA Zhen, Mingming,et al."Maximizing the Relaxivity of Gd-Complex by Synergistic Effect of HSA and Carboxylfullerene".ACS APPLIED MATERIALS & INTERFACES 4.7(2012):3724-3729.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhen, Mingming]'s Articles
[Zheng, Junpeng]'s Articles
[Ye, Lei]'s Articles
百度学术
百度学术Similar articles in
[Zhen, Mingming]'s Articles
[Zheng, Junpeng]'s Articles
[Ye, Lei]'s Articles
必应学术
必应学术Similar articles in
[Zhen, Mingming]'s Articles
[Zheng, Junpeng]'s Articles
[Ye, Lei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.