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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
The inferiority of G-PB to rhG-CSF-mobilized blood and marrow grafts as a stem cell source in patients with high-risk acute leukemia who underwent unmanipulated HLA-mismatched/haploidentical transplantation: a comparative analysis
作者: Xu, L-P; Liu, K-Y; Liu, D-H; Chen, H.; Han, W.; Chen, Y-H; Wang, Y.; Huang, X-J
关键词: PBSCT ; haploidentical ; hematological malignancies
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2010-06-01
DOI: 10.1038/bmt.2009.311
卷: 45, 期:6, 页:985-992
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: DONOR LYMPHOCYTE INFUSION ; BONE-MARROW ; HEMATOLOGICAL MALIGNANCIES ; RELAPSE ; PROPHYLAXIS ; RECIPIENTS ; DEPLETION ; DISEASE
英文摘要:

The purpose of this study was to investigate the efficacy and feasibility of unmanipulated haploidentical PBSCT for the treatment of acute leukemia (AL). This study compares the clinical outcomes of high-risk AL patients who received PBSCs harvested from family members sharing at least one common haplotype to outcomes of high-risk AL patients who received a mixture of G-CSF-primed BM (G-BM) and peripheral blood (G-PB) harvests. The results show that PBSCT achieved inferior cumulative myeloid engraftment at 30 days after transplant (89.9+/-10.1% vs 100%; P=0.04), with lower cumulative incidence of grade II-IV acute GVHD (aGVHD) (37.1+/-16.5% vs 63.2+/-6%; P=0.058) compared with G-BM/G-PB transplant. However, both transplant protocols had similar rates of 2-year relapse (29.6+/-17.1% vs 34.0+/-5.7%; P=0.954), and PBSCT produced a higher incidence of 2-year non-leukemic mortality (62.5+/-14.8% vs 35.1+/-5.1%; P=0.014), as well as lower rates of overall (26.8+/-12.3% vs 43.2+/-5.0%; P=0.052) and disease-free survival (26.8+/-12.3% vs 42.4+/-5.0%; P=0.071) compared with G-BM/G-PB transplant. These results suggest that haploidentical HSCT is an option for patients with AL who urgently need a graft and do not have matched sibling donors. PBSCT is potentially inferior to G-BM/G-PB transplant, and improvements should be made before PBSCT becomes a routine in unmanipulated mismatched/haploidentical transplant settings. Bone Marrow Transplantation (2010) 45, 985-992; doi:10.1038/bmt.2009.311; published online 9 November 2009

语种: 英语
所属项目编号: 30725038 ; IRT0702 ; 2006AA02Z4A0
项目资助者: National Outstanding Young Scientists&prime ; Foundation of China ; Program for Innovative Research Team in University ; HI-Tech Research Development Program of China 863
WOS记录号: WOS:000278573600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54944
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Dept Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Xu, L-P,Liu, K-Y,Liu, D-H,et al. The inferiority of G-PB to rhG-CSF-mobilized blood and marrow grafts as a stem cell source in patients with high-risk acute leukemia who underwent unmanipulated HLA-mismatched/haploidentical transplantation: a comparative analysis[J]. BONE MARROW TRANSPLANTATION,2010,45(6):985-992.
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