北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 期刊论文
学科主题: 口腔医学
题名:
The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers
作者: Yan, Na1; Zhang, Xuehui1; Cai, Qing2; Yang, Xiaoping2; Zhou, Xuegang2; Wang, Bo1; Deng, Xuliang1
关键词: Tetracycline ; PLGA ; electrospun nanofiber ; drug delivery
刊名: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
发表日期: 2012
DOI: 10.1163/092050611X568223
卷: 23, 期:8, 页:1005-1019
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]: Engineering ; Materials Science ; Polymer Science
关键词[WOS]: IN-VITRO ; DELIVERY SYSTEM ; CLINICAL-IMPLICATIONS ; LOCAL APPLICATION ; INFECTIONS ; SCAFFOLDS ; EFFICACY ; BETA ; NANOPARTICLES ; MICROSPHERES
英文摘要:

Electrospun tetracycline (Tet)-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers are considered to have great potential as local drug-delivery systems. This study was designed to explore the effects of the lactidyl/glycolidyl (LA/GA) unit ratio and molecular weight of PLGA on Tet entrapment efficiency and in vitro release kinetics. Three kinds of PLGA (PLGA75/25, M-w = 100 000 or 50 000; PLGA50/50, M-w = 50 000) were examined in this study. Electrospun nanofibers were fabricated containing 3, 5, 10 wt% Tet. The results showed that PLGA50/50 entrapped more Tet than both PLGA75/25 co-polymers, and the PLGA75/25 of M-w = 100 000 entrapped the least amount of Tet, suggesting that the lower the molecular weight of PLGA was, the higher the GA content in PLGA was and the higher the resulting Tet entrapment. Tet loading played an important role in Tet release. Nanofibers with 3 and 5 wt% Tet loading exhibited a sustained release for more than 28 days, whereas 10 wt% Tet only lasted 14 days. Loading of 3 wt% Tet resulted in approx. 35% release in the initial 12 h, 5 wt% Tet released approx. 70% and 10 wt% Tet resulted in approx. 85% release. The integrity of Tet incorporated into electrospun PLGA nanofibers was identified by FT-IR spectrum examination and the bacterial inhibition test. The modified Kirby-Bauer test showed dose-dependent inhibition of Staphylococcus aureus growth by Tet, confirming Tet structural stability throughout the electrospinning procedure. MG-63 cells demonstrated good adhesion and proliferation on all PLGA/Tet fibrous membranes. These results indicate that Tet entrapment and release kinetics of PLGA/Tet composite fibrous scaffolds can be tailored by the LA/GA ratios, molecular weights and drug loadings. Tet-loaded fibrous scaffolds show great potential for local drug delivery and bone defect repair. (C) Koninklijke Brill NV, Leiden, 2012

语种: 英语
所属项目编号: 50873012 ; 51073016 ; 2007AA021901 ; 2010 DFA51500
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; International Science and Technology Cooperation Program ; Program of New Century Excellent Talents (NCET) of Universities in China
WOS记录号: WOS:000302457200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54952
Appears in Collections:北京大学口腔医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China

Recommended Citation:
Yan, Na,Zhang, Xuehui,Cai, Qing,et al. The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2012,23(8):1005-1019.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yan, Na]'s Articles
[Zhang, Xuehui]'s Articles
[Cai, Qing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yan, Na]‘s Articles
[Zhang, Xuehui]‘s Articles
[Cai, Qing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace