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The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers
Yan, Na1; Zhang, Xuehui1; Cai, Qing2; Yang, Xiaoping2; Zhou, Xuegang2; Wang, Bo1; Deng, Xuliang1
关键词Tetracycline Plga Electrospun Nanofiber Drug Delivery
刊名JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
2012
DOI10.1163/092050611X568223
23期:8页:1005-1019
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]Engineering ; Materials Science ; Polymer Science
关键词[WOS]IN-VITRO ; DELIVERY SYSTEM ; CLINICAL-IMPLICATIONS ; LOCAL APPLICATION ; INFECTIONS ; SCAFFOLDS ; EFFICACY ; BETA ; NANOPARTICLES ; MICROSPHERES
英文摘要

Electrospun tetracycline (Tet)-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers are considered to have great potential as local drug-delivery systems. This study was designed to explore the effects of the lactidyl/glycolidyl (LA/GA) unit ratio and molecular weight of PLGA on Tet entrapment efficiency and in vitro release kinetics. Three kinds of PLGA (PLGA75/25, M-w = 100 000 or 50 000; PLGA50/50, M-w = 50 000) were examined in this study. Electrospun nanofibers were fabricated containing 3, 5, 10 wt% Tet. The results showed that PLGA50/50 entrapped more Tet than both PLGA75/25 co-polymers, and the PLGA75/25 of M-w = 100 000 entrapped the least amount of Tet, suggesting that the lower the molecular weight of PLGA was, the higher the GA content in PLGA was and the higher the resulting Tet entrapment. Tet loading played an important role in Tet release. Nanofibers with 3 and 5 wt% Tet loading exhibited a sustained release for more than 28 days, whereas 10 wt% Tet only lasted 14 days. Loading of 3 wt% Tet resulted in approx. 35% release in the initial 12 h, 5 wt% Tet released approx. 70% and 10 wt% Tet resulted in approx. 85% release. The integrity of Tet incorporated into electrospun PLGA nanofibers was identified by FT-IR spectrum examination and the bacterial inhibition test. The modified Kirby-Bauer test showed dose-dependent inhibition of Staphylococcus aureus growth by Tet, confirming Tet structural stability throughout the electrospinning procedure. MG-63 cells demonstrated good adhesion and proliferation on all PLGA/Tet fibrous membranes. These results indicate that Tet entrapment and release kinetics of PLGA/Tet composite fibrous scaffolds can be tailored by the LA/GA ratios, molecular weights and drug loadings. Tet-loaded fibrous scaffolds show great potential for local drug delivery and bone defect repair. (C) Koninklijke Brill NV, Leiden, 2012

语种英语
WOS记录号WOS:000302457200002
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54952
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_特诊科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Yan, Na,Zhang, Xuehui,Cai, Qing,et al. The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2012,23(8):1005-1019.
APA Yan, Na.,Zhang, Xuehui.,Cai, Qing.,Yang, Xiaoping.,Zhou, Xuegang.,...&Deng, Xuliang.(2012).The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,23(8),1005-1019.
MLA Yan, Na,et al."The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L-Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 23.8(2012):1005-1019.
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