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Effects of stress during reactivation on rewarding memory
Zhao, Mei; Zhang, Zhang-Yin; Zhai, Hai-Feng; Qiu, Yi; Lu, Lin
关键词Cocaine Conditioned Place Aversion Conditioned Place Preference Naloxone Reactivation Retrieval Stress Sucrose
刊名NEUROREPORT
2007-07-16
18期:11页:1153-1156
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; PROTEIN-SYNTHESIS ; RECONSOLIDATION ; RETRIEVAL ; AMYGDALA ; ADDICTION ; MORPHINE ; ERK ; CORTICOSTERONE
英文摘要

When a stabilized memory is recalled or reactivated, it becomes labile and sensitive to disruptors such as protein-synthesis inhibitors. Previous evidence demonstrates that stress modulates different aspects of memory. The role of stress during reactivation on rewarding or aversive memory is not known, however. This study examines the effects of stress on rewarding or aversive memory using the conditioned place preference or conditioned place aversion paradigm. Rats were trained to acquire a sucrose and cocaine-conditioned place preference or naloxone-conditioned place aversion. Subsequently, rats were reexposed to the previous sucrose-paired, cocaine-paired and naloxone-paired chamber for 10 min before experiencing the stressful Morris water maze. All rats were tested for conditioned place preference or conditioned place aversion after the stressful water-maze task. After 5-day repeated exposure to the previously reward-paired chamber and experiencing stress, cocaine-conditioned place preference disappeared and sucrose-conditioned place preference was reversed; however, after 5-day repeated exposure to the previously naloxone-paired chamber and experiencing stress, naloxone-conditioned place aversion was not significantly changed. Our results provide the first evidence that the rewarding memory may have been reduced by exposing rats to stress during reexposure to the reward-paired context, which suggests that manipulations of drug memory during reactivation can provide a potential treatment for drug addiction.

语种英语
WOS记录号WOS:000247920400013
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54964
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
2.Fudan Univ, Shanghai Med Sch, Shanghai, Peoples R China
3.Med Coll Georgia, Dept Physiol, Augusta, GA USA
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GB/T 7714
Zhao, Mei,Zhang, Zhang-Yin,Zhai, Hai-Feng,et al. Effects of stress during reactivation on rewarding memory[J]. NEUROREPORT,2007,18(11):1153-1156.
APA Zhao, Mei,Zhang, Zhang-Yin,Zhai, Hai-Feng,Qiu, Yi,&Lu, Lin.(2007).Effects of stress during reactivation on rewarding memory.NEUROREPORT,18(11),1153-1156.
MLA Zhao, Mei,et al."Effects of stress during reactivation on rewarding memory".NEUROREPORT 18.11(2007):1153-1156.
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