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IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科  > 期刊论文
学科主题: 口腔医学
题名:
Giant cell granuloma of the temporal bone - A case report with immunohistochemical, enzyme histochemical, and in vitro studies
作者: Tian, XF; Li, TJ; Yu, SF
刊名: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
发表日期: 2003-09-01
卷: 127, 期:9, 页:1217-1220
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]: Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology
关键词[WOS]: REPARATIVE GRANULOMA ; LESIONS
英文摘要:

A case of giant cell granuloma (GCG) that occurred in the right temporal bone is reported. The lesion showed histologic features identical to GCG. The multinuclear giant cells (MGCs) in the lesion showed strong reactivity with CD68, but patchy staining for myeloid/histiocyte antigen, alpha-1-antitrypsin, alpha-1-antichymotrypsine, and lysozyme. Activity of tartrate-resistant acid phosphatase was also consistently detected in the MGCs. Some of the mononuclear cells of the lesion exhibited similar immunocytochemical and histochemical reactivity as the MGCs. Ki-67 staining, however, was only detected in the mononuclear cells. The MGCs isolated from the lesion presented characteristic morphology of osteoclasts and possessed the ability to excavate bone in vitro. Thus, the MGCs in GCG appeared to express both macrophage- and osteoclast-associated phenotypes. The mononuclear cells were the major proliferative elements in the lesion and a subpopulation of these cells may represent precursors of the MGCs.

语种: 英语
WOS记录号: WOS:000185240300030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54969
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

Recommended Citation:
Tian, XF,Li, TJ,Yu, SF. Giant cell granuloma of the temporal bone - A case report with immunohistochemical, enzyme histochemical, and in vitro studies[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2003,127(9):1217-1220.
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