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学科主题: 精神卫生
题名:
Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population
作者: Qian, Qiujin; Wang, Yufeng; Li, Jun; Yang, Li; Wang, Bing; Zhou, Rulun; Glatt, Stephen J.; Faraone, Stephen V.
关键词: attention-deficit/hyperactivity disorder ; gene ; dopamine D4 receptor ; dopamine transporter ; catechol-O-methyltransferase ; dopamine D2 receptor ; interaction
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2007-03-05
DOI: 10.1002/ajmg.b.30422
卷: 144B, 期:2, 页:200-206
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: CATECHOL-O-METHYLTRANSFERASE ; DOPAMINE TRANSPORTER GENE ; CASE-CONTROL ASSOCIATION ; DEFICIT/HYPERACTIVITY DISORDER ; NO ASSOCIATION ; RECEPTOR GENE ; MICE LACKING ; ALLELE ; DAT1 ; ADHD
英文摘要:

Several lines of evidence suggest that attention-deficit/hyperactivity disorder (ADHD) is a polygenic disorder produced by the interaction of several genes with minor effects. To explore potential gene-gene interactions among candidate genes for ADHD, we studied the dopamine D2 receptor (DRD2), dopamine D4 receptor (DRD4), dopamine transporter (DAT1), and catechol-O-methyltransferase (COMT) genes in the Han Chinese population. A sample of 340 children with ADHD was diagnosed according to the DSM-IV criteria. We also recruited 226 unrelated controls. Identified polymorphisms included a 48-basepair-repeat in Exon 3 of DRD4, a 40-base-pair-repeat in the 3′ untranslated region of DAT1, a restriction-fragment-length polymorphism at codon 158 of COMT, and a -241A > G transition in the promoter of DRD2. Associations of polymorphisms with ADHD and its subtypes were examined by comparing allele frequencies between probands and controls. Binary logistic regression analysis was used to examine the potential gene-gene interactions. Binary logistic regression analysis with the sample of refined phenotypes showed that male gender and long-repeat genotypes of DRD4 and DAT1. were independent risk factors for ADHD. We found no evidence for gene-gene interactions among the candidate genes studied. The present study suggests that dopamine candidate genes are associated with increased vulnerability to ADHD in the Han Chinese population. (c) 2006 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000244729000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54970
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Univ Calif San Diego, Inst Behav Genom, Dept Psychiat, La Jolla, CA 92093 USA
3.SUNY Syracuse, Med Genet Res Ctr, Syracuse, NY 13210 USA
4.SUNY Syracuse, Dept Psychiat, Syracuse, NY 13210 USA

Recommended Citation:
Qian, Qiujin,Wang, Yufeng,Li, Jun,et al. Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(2):200-206.
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