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Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population
Qian, Qiujin; Wang, Yufeng; Li, Jun; Yang, Li; Wang, Bing; Zhou, Rulun; Glatt, Stephen J.; Faraone, Stephen V.
关键词Attention-deficit/hyperactivity Disorder Gene Dopamine D4 Receptor Dopamine Transporter Catechol-o-methyltransferase Dopamine D2 Receptor Interaction
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2007-03-05
DOI10.1002/ajmg.b.30422
144B期:2页:200-206
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]CATECHOL-O-METHYLTRANSFERASE ; DOPAMINE TRANSPORTER GENE ; CASE-CONTROL ASSOCIATION ; DEFICIT/HYPERACTIVITY DISORDER ; NO ASSOCIATION ; RECEPTOR GENE ; MICE LACKING ; ALLELE ; DAT1 ; ADHD
英文摘要

Several lines of evidence suggest that attention-deficit/hyperactivity disorder (ADHD) is a polygenic disorder produced by the interaction of several genes with minor effects. To explore potential gene-gene interactions among candidate genes for ADHD, we studied the dopamine D2 receptor (DRD2), dopamine D4 receptor (DRD4), dopamine transporter (DAT1), and catechol-O-methyltransferase (COMT) genes in the Han Chinese population. A sample of 340 children with ADHD was diagnosed according to the DSM-IV criteria. We also recruited 226 unrelated controls. Identified polymorphisms included a 48-basepair-repeat in Exon 3 of DRD4, a 40-base-pair-repeat in the 3′ untranslated region of DAT1, a restriction-fragment-length polymorphism at codon 158 of COMT, and a -241A > G transition in the promoter of DRD2. Associations of polymorphisms with ADHD and its subtypes were examined by comparing allele frequencies between probands and controls. Binary logistic regression analysis was used to examine the potential gene-gene interactions. Binary logistic regression analysis with the sample of refined phenotypes showed that male gender and long-repeat genotypes of DRD4 and DAT1. were independent risk factors for ADHD. We found no evidence for gene-gene interactions among the candidate genes studied. The present study suggests that dopamine candidate genes are associated with increased vulnerability to ADHD in the Han Chinese population. (c) 2006 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000244729000007
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54970
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Univ Calif San Diego, Inst Behav Genom, Dept Psychiat, La Jolla, CA 92093 USA
3.SUNY Syracuse, Med Genet Res Ctr, Syracuse, NY 13210 USA
4.SUNY Syracuse, Dept Psychiat, Syracuse, NY 13210 USA
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Qian, Qiujin,Wang, Yufeng,Li, Jun,et al. Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(2):200-206.
APA Qian, Qiujin.,Wang, Yufeng.,Li, Jun.,Yang, Li.,Wang, Bing.,...&Faraone, Stephen V..(2007).Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(2),200-206.
MLA Qian, Qiujin,et al."Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.2(2007):200-206.
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