北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 北京大学糖尿病中心  > 期刊论文
学科主题: 基础医学
题名:
Peroxisome proliferator-activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice
作者: Cha, Dae Ryong; Zhang, Xiaoyan; Zhang, Yahua; Wu, Jing; Su, Dongming; Han, Jee Young; Fang, Xuefen; Yu, Bo; Breyer, Matthew D.; Guan, Youfei
刊名: DIABETES
发表日期: 2007-08-01
DOI: 10.2337/db06-1134
卷: 56, 期:8, 页:2036-2045
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMPROVES INSULIN SENSITIVITY ; PPAR-ALPHA ; GAMMA AGONIST ; METABOLIC ABNORMALITIES ; NUCLEAR RECEPTORS ; LIPID-METABOLISM ; BODY-WEIGHT ; IN-VITRO ; RESISTANCE ; RATS
英文摘要:

Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors and play a central role in insulin sensitivity, lipid metabolism, and inflammation. Both PPAR alpha and -gamma are expressed in the kidney, and their agonists exhibit renoprotective effects in type 2 diabetes. In the present studies, we investigated the effect of the PPAR alpha/gamma dual agonist tesaglitazar on diabetic nephropathy in type 2 diabetic db/db mice. Treatment of db/db mice with tesaglitazar for 3 months significantly lowered fasting plasma glucose and homeostasis model assessment of insulin resistance levels but had little effect on body weight, adiposity, or cardiac function. Treatment with tesaglitazar was associated with reduced plasma insulin and total triglyceride levels and increased plasma adiponectin levels. Notably, tesaglitazar markedly attenuated albuminuria and significantly lowered glomerulofibrosis, collagen deposition, and transforming growth factor-beta 1 expression in renal tissues of db/db mice. In cultured mesangial cells and proximal tubule cells, where both PPAR alpha and -gamma were expressed, tesaglitazar treatment abolished high glucose- induced total collagen protein production and type I and IV collagen gene expression. Collectively, tesaglitazar treat ment not only improved insulin resistance, glycemic control, and lipid profile but also markedly attenuated albuminuria and renal glomerular fibrosis in db/db mice. These findings support the utility of dual PPAR alpha/gamma agonists in treating type 2 diabetes and diabetic nephropathy.

语种: 英语
WOS记录号: WOS:000248473100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54972
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
2036.full.pdf(641KB)期刊论文作者接受稿限制开放 联系获取全文

作者单位: 1.Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol & Hypertens, Nashville, TN USA
2.Peking Univ, Ctr Diabet, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Cha, Dae Ryong,Zhang, Xiaoyan,Zhang, Yahua,et al. Peroxisome proliferator-activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice[J]. DIABETES,2007,56(8):2036-2045.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cha, Dae Ryong]'s Articles
[Zhang, Xiaoyan]'s Articles
[Zhang, Yahua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cha, Dae Ryong]‘s Articles
[Zhang, Xiaoyan]‘s Articles
[Zhang, Yahua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace