|Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis|
|Zhao, Yi1; Tao, Jining2; Tu, Ping1|
|关键词||Erythema Index Imagej Photodynamic Therapy Port-wine Stains|
|刊名||PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY|
|WOS标题词||Science & Technology|
|关键词[WOS]||LASER THERAPY ; COLOR ; QUANTIFICATION ; MULTICENTER ; MELANIN|
Background: Methods for quantitatively evaluate the efficacy of photodynamic therapy (PDT) for port-wine stains (PWS) are still needed for clinical practice and studies.
Methods: 50 pairs of pictures before and after PDT of 40 PWS patients were selected. Each PWS lesion was labeled with a marker of red color graded 0-9. These pictures were taken without assistance of instruments to keep same position or distance and were referred to as ′experimental′ images. 70 labels were photographed at a fixed position and distance with the assistance of a bracket and the images obtained were referred to as ′standardized′ ones. An independent group of three experts viewed the photos and assessed the efficacy. The images were processed and measured for erythema index (EI) with the ImageJ freeware. The EI difference (Delta EI) and the percent change of Delta EI ((ratio)Delta EI(%)) of the labels and the PWS lesions was computed separately.
Results: Significant differences of EI, Delta EI and (ratio)Delta EI(%) were found between each two grades of the color markers in both standardized and experimental images. Delta EI of lesions achieved ′almost cured′ and ′great improvement′ after PDT was significantly reduced than before PDT. Significantly greater percentages of lesions were assessed as ′response′ and ′significant response′ in those of (before)Delta EI >= 35 compared to those of (before)Delta EI < 35. The (ratio)Delta EI(%) decrease of lesions assessed as ′almost cured′, ′great improvement′ and ′some improvement′ was significantly reduced sequentially.
Conclusion: The EI image analysis is a valid method for quantitatively evaluating efficacy of PDT for PWS. (c) 2012 Elsevier B.V. All rights reserved.
|作者单位||1.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China|
2.Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, Shanghai, Peoples R China
|Zhao, Yi,Tao, Jining,Tu, Ping. Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2013,10(2):96-102.|
|APA||Zhao, Yi,Tao, Jining,&Tu, Ping.(2013).Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,10(2),96-102.|
|MLA||Zhao, Yi,et al."Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 10.2(2013):96-102.|