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Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis
Zhao, Yi1; Tao, Jining2; Tu, Ping1
关键词Erythema Index Imagej Photodynamic Therapy Port-wine Stains
刊名PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
2013-05-01
DOI10.1016/j.pdpdt.2012.10.001
10期:2页:96-102
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]LASER THERAPY ; COLOR ; QUANTIFICATION ; MULTICENTER ; MELANIN
英文摘要

Background: Methods for quantitatively evaluate the efficacy of photodynamic therapy (PDT) for port-wine stains (PWS) are still needed for clinical practice and studies.

Methods: 50 pairs of pictures before and after PDT of 40 PWS patients were selected. Each PWS lesion was labeled with a marker of red color graded 0-9. These pictures were taken without assistance of instruments to keep same position or distance and were referred to as ′experimental′ images. 70 labels were photographed at a fixed position and distance with the assistance of a bracket and the images obtained were referred to as ′standardized′ ones. An independent group of three experts viewed the photos and assessed the efficacy. The images were processed and measured for erythema index (EI) with the ImageJ freeware. The EI difference (Delta EI) and the percent change of Delta EI ((ratio)Delta EI(%)) of the labels and the PWS lesions was computed separately.

Results: Significant differences of EI, Delta EI and (ratio)Delta EI(%) were found between each two grades of the color markers in both standardized and experimental images. Delta EI of lesions achieved ′almost cured′ and ′great improvement′ after PDT was significantly reduced than before PDT. Significantly greater percentages of lesions were assessed as ′response′ and ′significant response′ in those of (before)Delta EI >= 35 compared to those of (before)Delta EI < 35. The (ratio)Delta EI(%) decrease of lesions assessed as ′almost cured′, ′great improvement′ and ′some improvement′ was significantly reduced sequentially.

Conclusion: The EI image analysis is a valid method for quantitatively evaluating efficacy of PDT for PWS. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000321536400002
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54973
专题北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
2.Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yi,Tao, Jining,Tu, Ping. Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,2013,10(2):96-102.
APA Zhao, Yi,Tao, Jining,&Tu, Ping.(2013).Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis.PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY,10(2),96-102.
MLA Zhao, Yi,et al."Quantitative evaluation of efficacy of photodynamic therapy for port-wine stains using erythema index image analysis".PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 10.2(2013):96-102.
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