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学科主题: 基础医学
题名:
BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta
作者: Mei, Fan1,2; Nagappan, Guhan2,3; Ke, Yang1; Sacktor, Todd C.4,5; Lu, Bai2,3
刊名: PLOS ONE
发表日期: 2011-06-29
DOI: 10.1371/journal.pone.0021568
卷: 6, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: LONG-TERM POTENTIATION ; KINASE-M-ZETA ; SYNAPTIC PLASTICITY ; MEMORY ; HIPPOCAMPUS ; TRAFFICKING ; EXPRESSION ; INCREASES
英文摘要:

Late-phase long term potentiation (L-LTP) is thought to be the cellular basis for long-term memory (LTM). While LTM as well as L-LTP is known to depend on transcription and translation, it is unclear why brain-derived neurotrophic factor (BDNF) could sustain L-LTP when protein synthesis is inhibited. The persistently active protein kinase zeta (PKM zeta) is the only molecule implicated in perpetuating L-LTP maintenance. Here, in mouse acute brain slices, we show that inhibition of PKM zeta reversed BDNF-dependent form of L-LTP. While BDNF did not alter the steady-state level of PKM zeta, BDNF together with the L-LTP inducing theta-burst stimulation (TBS) increased PKM zeta level even without protein synthesis. Finally, in the absence of de novo protein synthesis, BDNF maintained TBS-induced PKM zeta at a sufficient level. These results suggest that BDNF sustains L-LTP through PKM zeta in a protein synthesis-independent manner, revealing an unexpected link between BDNF and PKM zeta.

语种: 英语
项目资助者: National Institutes of Child Health and Human Development ; National Institutes of Mental Health
WOS记录号: WOS:000292290100041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54974
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.GlaxoSmithKline, R&D China, Shanghai, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.NICHHD, Program Dev Neurobiol, Bethesda, MD 20892 USA
4.Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Robert F Furchgott Ctr Neural & Behav Sci, Brooklyn, NY 11203 USA
5.Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

Recommended Citation:
Mei, Fan,Nagappan, Guhan,Ke, Yang,et al. BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta[J]. PLOS ONE,2011,6(6).
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