IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta
Mei, Fan1,2; Nagappan, Guhan2,3; Ke, Yang1; Sacktor, Todd C.4,5; Lu, Bai2,3
刊名PLOS ONE
2011-06-29
DOI10.1371/journal.pone.0021568
6期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LONG-TERM POTENTIATION ; KINASE-M-ZETA ; SYNAPTIC PLASTICITY ; MEMORY ; HIPPOCAMPUS ; TRAFFICKING ; EXPRESSION ; INCREASES
英文摘要

Late-phase long term potentiation (L-LTP) is thought to be the cellular basis for long-term memory (LTM). While LTM as well as L-LTP is known to depend on transcription and translation, it is unclear why brain-derived neurotrophic factor (BDNF) could sustain L-LTP when protein synthesis is inhibited. The persistently active protein kinase zeta (PKM zeta) is the only molecule implicated in perpetuating L-LTP maintenance. Here, in mouse acute brain slices, we show that inhibition of PKM zeta reversed BDNF-dependent form of L-LTP. While BDNF did not alter the steady-state level of PKM zeta, BDNF together with the L-LTP inducing theta-burst stimulation (TBS) increased PKM zeta level even without protein synthesis. Finally, in the absence of de novo protein synthesis, BDNF maintained TBS-induced PKM zeta at a sufficient level. These results suggest that BDNF sustains L-LTP through PKM zeta in a protein synthesis-independent manner, revealing an unexpected link between BDNF and PKM zeta.

语种英语
WOS记录号WOS:000292290100041
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54974
Collection北京大学基础医学院
作者单位1.GlaxoSmithKline, R&D China, Shanghai, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.NICHHD, Program Dev Neurobiol, Bethesda, MD 20892 USA
4.Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Robert F Furchgott Ctr Neural & Behav Sci, Brooklyn, NY 11203 USA
5.Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA
Recommended Citation
GB/T 7714
Mei, Fan,Nagappan, Guhan,Ke, Yang,et al. BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta[J]. PLOS ONE,2011,6(6).
APA Mei, Fan,Nagappan, Guhan,Ke, Yang,Sacktor, Todd C.,&Lu, Bai.(2011).BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta.PLOS ONE,6(6).
MLA Mei, Fan,et al."BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKM zeta".PLOS ONE 6.6(2011).
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