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学科主题: 临床医学
题名:
Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis
作者: Ren, Ya-Li; Nong, Lin; Zhang, Shuang; Zhao, Jing; Zhang, Xiao-Ming; Li, Ting
关键词: Peripheral T-cell lymphoma ; NK-cell lymphoma ; Classification ; T-bet ; ETS1
刊名: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2012-09-01
DOI: 10.1309/AJCPWKJ3GPFRT7GA
卷: 138, 期:3, 页:435-447
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: CUTANEOUS LYMPHOCYTE ANTIGEN ; EPSTEIN-BARR-VIRUS ; NON-HODGKINS-LYMPHOMA ; NATURAL-KILLER-CELLS ; T-CELL ; EOMESODERMIN EXPRESSION ; TRANSCRIPTION FACTOR ; CLINICAL-OUTCOMES ; BET ; CHEMOTHERAPY
英文摘要:

Peripheral T- and natural killer (NK)-cell lymphomas (PTNKLs) are a heterogeneous group of lymphoid malignancies. We reclassified 142 cases and investigated their clinicopathologic features and outcome. Results showed that the most prevalent subtypes were extranodal NK/T-cell lymphoma, nasal type (eNK/T) (38.0%); angioimmunoblastic T-cell lymphoma (16.9%); and peripheral T-cell lymphoma, not otherwise specified (16.2%). Follow-up was available in 124 patients whose overall survival ranged from 3 days to 134 months, with a median of 11 months. Multivariate analysis demonstrated that thrombocytopenia (P = .001), elevated lactate dehydrogenase (P = .007), high Ki-67 index (P = .002), and T-bet expression in more than 20% of cells (P = .036) were independent factors for all cases-among which only the factor of T-bet indicated good outcome-and that thrombocytopenia (P = .011) and radiotherapy (P = .026) were significant for the eNK/T group. Thus, eNK/T was the commonest subtype in this series. The significance of T-bet in predicting outcome should be further confirmed.

语种: 英语
所属项目编号: 81071944 ; 30770910
项目资助者: National Natural Sciences Foundation of China, Beijing
WOS记录号: WOS:000308259800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54979
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: Peking Univ, Dept Pathol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Ren, Ya-Li,Nong, Lin,Zhang, Shuang,et al. Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2012,138(3):435-447.
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