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Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis
Ren, Ya-Li; Nong, Lin; Zhang, Shuang; Zhao, Jing; Zhang, Xiao-Ming; Li, Ting
关键词Peripheral T-cell Lymphoma Nk-cell Lymphoma Classification T-bet Ets1
刊名AMERICAN JOURNAL OF CLINICAL PATHOLOGY
2012-09-01
DOI10.1309/AJCPWKJ3GPFRT7GA
138期:3页:435-447
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]CUTANEOUS LYMPHOCYTE ANTIGEN ; EPSTEIN-BARR-VIRUS ; NON-HODGKINS-LYMPHOMA ; NATURAL-KILLER-CELLS ; T-CELL ; EOMESODERMIN EXPRESSION ; TRANSCRIPTION FACTOR ; CLINICAL-OUTCOMES ; BET ; CHEMOTHERAPY
英文摘要

Peripheral T- and natural killer (NK)-cell lymphomas (PTNKLs) are a heterogeneous group of lymphoid malignancies. We reclassified 142 cases and investigated their clinicopathologic features and outcome. Results showed that the most prevalent subtypes were extranodal NK/T-cell lymphoma, nasal type (eNK/T) (38.0%); angioimmunoblastic T-cell lymphoma (16.9%); and peripheral T-cell lymphoma, not otherwise specified (16.2%). Follow-up was available in 124 patients whose overall survival ranged from 3 days to 134 months, with a median of 11 months. Multivariate analysis demonstrated that thrombocytopenia (P = .001), elevated lactate dehydrogenase (P = .007), high Ki-67 index (P = .002), and T-bet expression in more than 20% of cells (P = .036) were independent factors for all cases-among which only the factor of T-bet indicated good outcome-and that thrombocytopenia (P = .011) and radiotherapy (P = .026) were significant for the eNK/T group. Thus, eNK/T was the commonest subtype in this series. The significance of T-bet in predicting outcome should be further confirmed.

语种英语
WOS记录号WOS:000308259800018
项目编号81071944 ; 30770910
资助机构National Natural Sciences Foundation of China, Beijing
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54979
专题北京大学第一临床医学院_病理科
北京大学第一临床医学院_电镜室
作者单位Peking Univ, Dept Pathol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
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Ren, Ya-Li,Nong, Lin,Zhang, Shuang,et al. Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2012,138(3):435-447.
APA Ren, Ya-Li,Nong, Lin,Zhang, Shuang,Zhao, Jing,Zhang, Xiao-Ming,&Li, Ting.(2012).Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis.AMERICAN JOURNAL OF CLINICAL PATHOLOGY,138(3),435-447.
MLA Ren, Ya-Li,et al."Analysis of 142 Northern Chinese Patients With Peripheral T/NK-Cell Lymphomas Subtype Distribution, Clinicopathologic Features, and Prognosis".AMERICAN JOURNAL OF CLINICAL PATHOLOGY 138.3(2012):435-447.
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