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学科主题: 口腔医学
题名:
Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide
作者: Han, Bing1,2; Wang, Xiaoyan1,2; Gao, Xuejun1,2; Liu, Jiguang3; Liang, Fuxin3; Qu, Xiaozhong3; Yang, Zhenzhong3
关键词: microcapsule ; polymer ; calcium hydroxide ; controlled release ; dental/craniofacial material
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
发表日期: 2011-10-01
DOI: 10.1002/jbm.b.31878
卷: 99B, 期:1, 页:120-126
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: IN-VITRO ; MICROSPHERES ; ETHYLCELLULOSE ; RELEASE ; VIVO ; POLY(LACTIDE-CO-GLYCOLIDE) ; MICROENCAPSULATION ; VEHICLES
英文摘要:

This study aimed to synthesize and characterize biodegradable microcapsules based on poly(lactic acid) (PLA) and ethylcellulose (EC) for a controlled delivery of calcium hydroxide. Phase separation technique was adopted to synthesize calcium hydroxide-loaded PLA/EC microcapsules. Four PLA/EC blends (4/1, 1/1, 1/4, pure EC) were used as shell materials and the input ratio of calcium hydroxide to shell polymer was 4: 1 for all microcapsules. The morphology and composition were studied using SEM-EDS and TEM. Particle size distribution, glass-transition temperature, drug loading, and encapsulation efficiency were characterized. In vitro release of the microcapsules was evaluated using a pH microelectrode and an auto-biochemistry analyzer. SEM images of microcapsules showed uniform spherical structures with smooth surfaces. Core-shell, hetero-structures were confirmed using TEM. The presence of calcium in the microcapsules was verified with EDS. Pure calcium hydroxide was 160 nm in diameter and the particle size of the microcapsules ranged between 500 nm and 4 mu m. With an increase of PLA in PLA/EC blend, the size of microcapsules increased accordingly. Encapsulation efficiency of these microcapsules was higher than 57% and drug loading was higher than 80%, which were not significantly different among four microcapsules. Pure calcium hydroxide powder was used as a control and 90% was released within 48 h, while release of calcium hydroxide from microcapsules took between 168 and 456 h, depending on the PLA/EC ratio. Compared with calcium hydroxide powder, the calcium hydroxide-loaded microcapsules showed a sustained and prolonged release, which could be controlled via the regulation of the PLA/EC ratio. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 99B: 120-126, 2011.

语种: 英语
所属项目编号: 2007BAI18B01
项目资助者: Ministry of Science and Technology of China ; Ministry of Health, PR China
WOS记录号: WOS:000294912400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54983
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China
3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China

Recommended Citation:
Han, Bing,Wang, Xiaoyan,Gao, Xuejun,et al. Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2011,99B(1):120-126.
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