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Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide
Han, Bing1,2; Wang, Xiaoyan1,2; Gao, Xuejun1,2; Liu, Jiguang3; Liang, Fuxin3; Qu, Xiaozhong3; Yang, Zhenzhong3
关键词Microcapsule Polymer Calcium Hydroxide Controlled Release Dental/craniofacial Material
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
2011-10-01
DOI10.1002/jbm.b.31878
99B期:1页:120-126
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]IN-VITRO ; MICROSPHERES ; ETHYLCELLULOSE ; RELEASE ; VIVO ; POLY(LACTIDE-CO-GLYCOLIDE) ; MICROENCAPSULATION ; VEHICLES
英文摘要

This study aimed to synthesize and characterize biodegradable microcapsules based on poly(lactic acid) (PLA) and ethylcellulose (EC) for a controlled delivery of calcium hydroxide. Phase separation technique was adopted to synthesize calcium hydroxide-loaded PLA/EC microcapsules. Four PLA/EC blends (4/1, 1/1, 1/4, pure EC) were used as shell materials and the input ratio of calcium hydroxide to shell polymer was 4: 1 for all microcapsules. The morphology and composition were studied using SEM-EDS and TEM. Particle size distribution, glass-transition temperature, drug loading, and encapsulation efficiency were characterized. In vitro release of the microcapsules was evaluated using a pH microelectrode and an auto-biochemistry analyzer. SEM images of microcapsules showed uniform spherical structures with smooth surfaces. Core-shell, hetero-structures were confirmed using TEM. The presence of calcium in the microcapsules was verified with EDS. Pure calcium hydroxide was 160 nm in diameter and the particle size of the microcapsules ranged between 500 nm and 4 mu m. With an increase of PLA in PLA/EC blend, the size of microcapsules increased accordingly. Encapsulation efficiency of these microcapsules was higher than 57% and drug loading was higher than 80%, which were not significantly different among four microcapsules. Pure calcium hydroxide powder was used as a control and 90% was released within 48 h, while release of calcium hydroxide from microcapsules took between 168 and 456 h, depending on the PLA/EC ratio. Compared with calcium hydroxide powder, the calcium hydroxide-loaded microcapsules showed a sustained and prolonged release, which could be controlled via the regulation of the PLA/EC ratio. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 99B: 120-126, 2011.

语种英语
WOS记录号WOS:000294912400014
项目编号2007BAI18B01
资助机构Ministry of Science and Technology of China ; Ministry of Health, PR China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54983
专题北京大学口腔医学院
北京大学口腔医学院_牙体牙髓科
作者单位1.Peking Univ, Sch Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China
3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Han, Bing,Wang, Xiaoyan,Gao, Xuejun,et al. Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2011,99B(1):120-126.
APA Han, Bing.,Wang, Xiaoyan.,Gao, Xuejun.,Liu, Jiguang.,Liang, Fuxin.,...&Yang, Zhenzhong.(2011).Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,99B(1),120-126.
MLA Han, Bing,et al."Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 99B.1(2011):120-126.
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