IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients
Yang, Yongfeng2,3; Li, Wenqiang2,3; Zhao, Jingyuan2; Zhang, Hongxing2,3; Song, Xueqin4; Xiao, Bo2,3; Yang, Ge2,3; Jiang, Chengdi2,3; Zhang, Dai1; Yue, Weihua1; Lv, Luxian2,3
关键词Schizophrenia Ghrelin (Ghrl) Polymorphrism Body Mass Index (Bmi) Atypical Antipsychotics Therapeutic Effects
刊名BEHAVIORAL AND BRAIN FUNCTIONS
2012-02-28
DOI10.1186/1744-9081-8-11
8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; INDUCED WEIGHT-GAIN ; BODY-MASS INDEX ; PERIPHERAL-BLOOD ; FOOD-INTAKE ; VARIANTS ; OLANZAPINE ; HORMONE ; COHORT ; ADIPONECTIN
英文摘要

Background: Ghrelin (GHRL) is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG) is a common side effect of the atypical antipsychotics (AAPs) used to treat schizophrenia (SZ). Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI). However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response.

Methods: Four SNPs (Leu72Met, -501A/C, -604 G/A, and -1062 G > C) were genotyped in 634 schizophrenia patients and 606 control subjects.

Results: There were no significant differences in allele frequencies, genotype distributions, or the distributions of two SNP haplotypes between SZ patients and healthy controls (P > 0.05). There was also no significant difference in symptom reduction between genotypes after 8 weeks of AAP treatment as measured by positive and negative symptom scale scores (PANSS). However, the -604 G/A polymorphism was associated with a greater BMI increase in response to AAP administration in both APP responders and non-responders as distinguished by PANSS score reduction (P < 0.001). There were also significant differences in WG when the responder group was further subdivided according to the specific AAP prescribed (P < 0.05).

Conclusions: These four GHRL gene SNPs were not associated with SZ in this Chinese Han population. The -604 G/A polymorphism was associated with significant BW and BMI increases during AAP treatment. Patients exhibiting higher WG showed greater improvements in positive and negative symptoms than patients exhibiting lower weight gain or weight loss.

语种英语
WOS记录号WOS:000303011500001
项目编号200801009 ; 2008IRTSTHN008 ; 30530290 ; 81071090 ; 81071091 ; 2009AA022702 ; 2007CB512301
资助机构Ministry of Health of the People&prime ; s Republic of China ; Program for Innovative Research Team (in Science and Technology) in University of Henan Province ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54997
专题北京大学精神卫生研究所
作者单位1.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China
4.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
推荐引用方式
GB/T 7714
Yang, Yongfeng,Li, Wenqiang,Zhao, Jingyuan,et al. Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2012,8.
APA Yang, Yongfeng.,Li, Wenqiang.,Zhao, Jingyuan.,Zhang, Hongxing.,Song, Xueqin.,...&Lv, Luxian.(2012).Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients.BEHAVIORAL AND BRAIN FUNCTIONS,8.
MLA Yang, Yongfeng,et al."Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients".BEHAVIORAL AND BRAIN FUNCTIONS 8(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Yongfeng]的文章
[Li, Wenqiang]的文章
[Zhao, Jingyuan]的文章
百度学术
百度学术中相似的文章
[Yang, Yongfeng]的文章
[Li, Wenqiang]的文章
[Zhao, Jingyuan]的文章
必应学术
必应学术中相似的文章
[Yang, Yongfeng]的文章
[Li, Wenqiang]的文章
[Zhao, Jingyuan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。