北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Gender and stimulus difference in cue-induced responses in abstinent heroin users
作者: Yu, Jiang; Zhang, Shun; Epstein, David H.; Fang, Yuxia; Shi, Jie; Qin, Hufu; Yao, Shujun; Le Foll, Bernard; Lu, Lin
关键词: heroin abuse ; cue reactivity ; craving ; gender difference ; cue paradigm
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2007-03-01
DOI: 10.1016/j.pbb.2007.01.008
卷: 86, 期:3, 页:485-492
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: COCAINE-DEPENDENT INDIVIDUALS ; CONDITIONED PLACE PREFERENCE ; SEX-DIFFERENCES ; ABUSE PATIENTS ; DRUG-ABUSE ; REACTIVITY ; ADDICTION ; RELAPSE ; STRESS ; EXPOSURE
英文摘要:

Background: Environmental stimuli associated with drug taking have been known to elicit drug craving and increase the likelihood of relapse, and sex differences have been observed in the development of drug addiction and relapse to drug taking. Differential cue paradigms (drug-related imagery scripts and drug-related paraphernalia) have been used to investigate cue-induced drug craving. However, there is little research on the possible gender differences in responses to drug cues in heroin-dependent individuals. This study examined whether two different stimuli, drugrelated imagery scripts and drug-related paraphernalia, produce similar or different patterns of cue reactivity in heroin-dependent men and women.

Methods: In the laboratory sessions, 26 male and 23 female heroin-dependent subjects were exposed to script-guided imagery of heroin-related cue situations and to heroin-related paraphernalia (e.g., needles, syringes, spoons, cigarette filters, and aluminum foil). Heroin craving, subjective anxiety, emotion state ratings, and cardiovascular changes were assessed.

Results: Significant increases in heroin craving were seen with drug-imagery scripts or drug paraphernalia but not with neutral-relaxing imagery or neutral-item handling. In addition, drug imagery and paraphernalia produced significant increases in subjective anxiety, negative emotions, systolic and diastolic blood pressure, and heart rate, as well as decreases in positive emotion. Paraphernalia exposure was somewhat more effective than imagery scripts in inducing heroin craving, primarily reflecting a lower response to imagery scripts among men. Most other dependent measures also differed by gender, and each gender difference occurred with imagery scripts only or with paraphernalia only.

Conclusions: The present results indicate that heroin-imagery scripts and heroin paraphernalia each induce heroin craving and emotional and cardiovascular changes, but that the changes show a complex pattern of gender differences that may need to be taken into account in future laboratory studies. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000245961700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55006
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tangshan Mental Hlth Hosp, Tangshan 063004, Peoples R China
2.Tangshan Ankan Hosp, Tangshan 063000, Peoples R China
3.Univ Toronto, Toronto, ON, Canada
4.Peking Univ, Natl Inst Drug Dependence, Beijing 640041, Peoples R China
5.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA
6.Ctr Addict & Mental Hlth, Translat Addict Res Lab, Toronto, ON, Canada

Recommended Citation:
Yu, Jiang,Zhang, Shun,Epstein, David H.,et al. Gender and stimulus difference in cue-induced responses in abstinent heroin users[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2007,86(3):485-492.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Jiang]'s Articles
[Zhang, Shun]'s Articles
[Epstein, David H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Jiang]‘s Articles
[Zhang, Shun]‘s Articles
[Epstein, David H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace