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学科主题: 临床医学
题名:
Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B
作者: Pan, Xingfei1; Cao, Hong1; Lu, Jianxi2; Shu, Xin1; Xiong, Xiaojia3; Hong, Xiaolv1; Xu, Qihuan1; Zhu, Huifen4; Li, Gang1; Shen, Guanxin4
关键词: IL-32 ; HBx ; Promoter ; NF-kappa B
刊名: MOLECULAR IMMUNOLOGY
发表日期: 2011-07-01
DOI: 10.1016/j.molimm.2011.03.012
卷: 48, 期:12-13, 页:1573-1577
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Immunology
关键词[WOS]: INCREASES MIGRATION ; VIRAL-INFECTIONS ; IMMUNE-RESPONSE ; HEPATOCYTES ; CYTOKINE ; IL-32 ; CELLS ; LEUKOCYTES ; MECHANISM ; PATHWAY
英文摘要:

HBV replicates noncytopathically in hepatocytes, but HBV or proteins encoded by HBV genome could induce cytokines. chemokines expression by hepatocytes. Moreover, liver damage in patients with HBV infection is immune-mediated and cytokines play important roles in immune-mediated liver damage after HBV infection. Interleukin-32 (IL-32) is a proinflammatory cytokine and plays a critical role in inflammation. However, the role of HBV in IL-32 expression remains unclear. In the present study, we demonstrate that hepatitis B virus protein X (HBx) increases IL-32 expression through the promoter of IL-32 at positions from -746 to +25 and in a dose-dependent manner. Furthermore, we demonstrate that increase of NF-kappa B subunits p65 and p50 in Huh7 cells also augments IL-32 expression, and the NF-kappa B inhibitor blocks the effect of HBx on IL-32 induction. These results indicate that NF-kappa B activation is required for HBx-induced IL-32 expression. In conclusion, IL-32 is induced by HBx in Huh7 cells. Our results suggest that IL-32 might play an important role in inflammatory response after HBV infection. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008B030301101 ; 2007CB512900 ; 2008ZX10002-009 ; NCET-04-0797
项目资助者: Science and Technology Planning Project of Guangdong Province, China ; Personnel returned personnel activities in science and technology project ; National Key and Basic Research Development Program of China ; State Project on Major Infectious Diseases Prevention ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000292444100027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55007
Appears in Collections:北京大学深圳医院_感染性疾病科_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou 510630, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 3, Vaccine Res Inst, Guangzhou 510630, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Infect Dis, Shenzhen 518036, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China

Recommended Citation:
Pan, Xingfei,Cao, Hong,Lu, Jianxi,et al. Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B[J]. MOLECULAR IMMUNOLOGY,2011,48(12-13):1573-1577.
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