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Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B
Pan, Xingfei1; Cao, Hong1; Lu, Jianxi2; Shu, Xin1; Xiong, Xiaojia3; Hong, Xiaolv1; Xu, Qihuan1; Zhu, Huifen4; Li, Gang1; Shen, Guanxin4
关键词Il-32 Hbx Promoter Nf-kappa b
刊名MOLECULAR IMMUNOLOGY
2011-07-01
DOI10.1016/j.molimm.2011.03.012
48期:12-13页:1573-1577
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Immunology
关键词[WOS]INCREASES MIGRATION ; VIRAL-INFECTIONS ; IMMUNE-RESPONSE ; HEPATOCYTES ; CYTOKINE ; IL-32 ; CELLS ; LEUKOCYTES ; MECHANISM ; PATHWAY
英文摘要

HBV replicates noncytopathically in hepatocytes, but HBV or proteins encoded by HBV genome could induce cytokines. chemokines expression by hepatocytes. Moreover, liver damage in patients with HBV infection is immune-mediated and cytokines play important roles in immune-mediated liver damage after HBV infection. Interleukin-32 (IL-32) is a proinflammatory cytokine and plays a critical role in inflammation. However, the role of HBV in IL-32 expression remains unclear. In the present study, we demonstrate that hepatitis B virus protein X (HBx) increases IL-32 expression through the promoter of IL-32 at positions from -746 to +25 and in a dose-dependent manner. Furthermore, we demonstrate that increase of NF-kappa B subunits p65 and p50 in Huh7 cells also augments IL-32 expression, and the NF-kappa B inhibitor blocks the effect of HBx on IL-32 induction. These results indicate that NF-kappa B activation is required for HBx-induced IL-32 expression. In conclusion, IL-32 is induced by HBx in Huh7 cells. Our results suggest that IL-32 might play an important role in inflammatory response after HBV infection. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000292444100027
项目编号2008B030301101 ; 2007CB512900 ; 2008ZX10002-009 ; NCET-04-0797
资助机构Science and Technology Planning Project of Guangdong Province, China ; Personnel returned personnel activities in science and technology project ; National Key and Basic Research Development Program of China ; State Project on Major Infectious Diseases Prevention ; Program for New Century Excellent Talents in University
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55007
专题北京大学深圳医院_感染性疾病科
作者单位1.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou 510630, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 3, Vaccine Res Inst, Guangzhou 510630, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Infect Dis, Shenzhen 518036, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China
推荐引用方式
GB/T 7714
Pan, Xingfei,Cao, Hong,Lu, Jianxi,et al. Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B[J]. MOLECULAR IMMUNOLOGY,2011,48(12-13):1573-1577.
APA Pan, Xingfei.,Cao, Hong.,Lu, Jianxi.,Shu, Xin.,Xiong, Xiaojia.,...&Shen, Guanxin.(2011).Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B.MOLECULAR IMMUNOLOGY,48(12-13),1573-1577.
MLA Pan, Xingfei,et al."Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappa B".MOLECULAR IMMUNOLOGY 48.12-13(2011):1573-1577.
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