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Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans
Liu, X. D.1; Duan, J.2; Guo, L. H.1
关键词Gene Inactivation Phosphoglucosamine Mutase Gene Streptococcus Mutans Virulence Properties
刊名ORAL MICROBIOLOGY AND IMMUNOLOGY
2009-08-01
24期:4页:272-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Immunology ; Microbiology
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Immunology ; Microbiology
关键词[WOS]PENICILLIN-BINDING PROTEINS ; BIOFILM FORMATION ; GENES ; IDENTIFICATION ; RESISTANCE ; SOBRINUS ; GORDONII
英文摘要

Introduction: Streptococcus mutans has been strongly implicated as the principal etiological agent in dental caries. As a gram-positive bacterium, S. mutans has a thick and compact cell wall to maintain the cell shape and protect the cells against mechanical or osmotic damage. Previous studies have proved that peptidoglycan is the main component of the cell wall involved in the autolysis or biofilm formation processes.

Methods: In this study, we investigated the gene SMU.1426c in the amino-sugar metabolism pathway of S. mutans UA159, which encodes phosphoglucosamine mutase (GlmM). The glmM gene that functions in the biosynthesis of peptidoglycan has been well investigated in Escherichia coli. Here a glmM mutant strain of S. mutans UA159 was constructed and several virulence properties were investigated.

Results: The mutant devoid of the glmM gene displayed long chains, reduced growth rate and increased autolysis. Biofilm formation by the mutant was found to be attenuated.

Conclusion: These results proved that peptidoglycan biosynthesis plays an important part in a series of bacterial morphologies. The glmM gene may have a constructive role in the virulence properties of S. mutans.

语种英语
WOS记录号WOS:000267072700002
项目编号30271417
资助机构Natural Sciences Foundation of China
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55008
专题北京大学口腔医学院_口腔生物研究室
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Biol, Beijing 100081, Peoples R China
2.Huzhou Teachers Coll, Sch Med, Dept Stomatol, Huzhou, Zhejiang, Peoples R China
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Liu, X. D.,Duan, J.,Guo, L. H.. Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans[J]. ORAL MICROBIOLOGY AND IMMUNOLOGY,2009,24(4):272-277.
APA Liu, X. D.,Duan, J.,&Guo, L. H..(2009).Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans.ORAL MICROBIOLOGY AND IMMUNOLOGY,24(4),272-277.
MLA Liu, X. D.,et al."Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans".ORAL MICROBIOLOGY AND IMMUNOLOGY 24.4(2009):272-277.
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