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学科主题: 口腔医学
题名:
Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans
作者: Liu, X. D.1; Duan, J.2; Guo, L. H.1
关键词: gene inactivation ; phosphoglucosamine mutase gene ; Streptococcus mutans ; virulence properties
刊名: ORAL MICROBIOLOGY AND IMMUNOLOGY
发表日期: 2009-08-01
卷: 24, 期:4, 页:272-277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Immunology ; Microbiology
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Immunology ; Microbiology
关键词[WOS]: PENICILLIN-BINDING PROTEINS ; BIOFILM FORMATION ; GENES ; IDENTIFICATION ; RESISTANCE ; SOBRINUS ; GORDONII
英文摘要:

Introduction: Streptococcus mutans has been strongly implicated as the principal etiological agent in dental caries. As a gram-positive bacterium, S. mutans has a thick and compact cell wall to maintain the cell shape and protect the cells against mechanical or osmotic damage. Previous studies have proved that peptidoglycan is the main component of the cell wall involved in the autolysis or biofilm formation processes.

Methods: In this study, we investigated the gene SMU.1426c in the amino-sugar metabolism pathway of S. mutans UA159, which encodes phosphoglucosamine mutase (GlmM). The glmM gene that functions in the biosynthesis of peptidoglycan has been well investigated in Escherichia coli. Here a glmM mutant strain of S. mutans UA159 was constructed and several virulence properties were investigated.

Results: The mutant devoid of the glmM gene displayed long chains, reduced growth rate and increased autolysis. Biofilm formation by the mutant was found to be attenuated.

Conclusion: These results proved that peptidoglycan biosynthesis plays an important part in a series of bacterial morphologies. The glmM gene may have a constructive role in the virulence properties of S. mutans.

语种: 英语
所属项目编号: 30271417
项目资助者: Natural Sciences Foundation of China
WOS记录号: WOS:000267072700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55008
Appears in Collections:北京大学口腔医学院_口腔生物研究室_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Biol, Beijing 100081, Peoples R China
2.Huzhou Teachers Coll, Sch Med, Dept Stomatol, Huzhou, Zhejiang, Peoples R China

Recommended Citation:
Liu, X. D.,Duan, J.,Guo, L. H.. Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans[J]. ORAL MICROBIOLOGY AND IMMUNOLOGY,2009,24(4):272-277.
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