IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Vascular Endothelial Growth Inhibitor 174 Is a Negative Regulator of Aggressiveness and Microvascular Density in Human Clear Cell Renal Cell Carcinoma
Wu, Liyang1; Li, Xiaobei1; Ye, Lin2; Shayiremu, Duoerkun3; Deng, Xiaohu4; Zhang, Xiaodong1; Jiang, Wenguo2,5,6; Yang, Yong7; Gong, Kan8; Zhang, Ning1,5,6
关键词Vascular Endothelial Growth Inhibitor 174 (Vegi 174) Microvessel Density (Mvd) Prognosis Clear Cell Renal Cell Carcinoma
刊名ANTICANCER RESEARCH
2014-02-01
34期:2页:715-722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Cancer Research Wales ; National Natural Science Foundation of China ; Cancer Research Wales
研究领域[WOS]Oncology
关键词[WOS]MICROVESSEL DENSITY ; BREAST-CANCER ; ELDERLY-PATIENTS ; NATURAL-HISTORY ; TNF LIGAND ; IN-VITRO ; ANGIOGENESIS ; EXPRESSION ; PROGNOSIS ; VEGI
英文摘要

Aims: To evaluate the role and expression of vascular endothelial growth inhibitor isoform 174 (VEGI 174) in the microvessels and its correlation with microvessel density (MVD) and prognosis of clear cell renal cell carcinoma (CCRCC). Materials and Methods: Immunohistochemical analysis was performed in 98 cases of renal cell carcinoma and paired normal kidney tissues for VEGI 174 and CD34. The clinical, pathological and follow-up (median follow-up: 54.5 months) information were recorded and analyzed against the VEGI174 and MVD expression. Results: There was an inverse correlation between VEGI 174 and MVD (r=-0.420, p<0.05) in normal human renal tissues and CCRCC specimens. Compared to normal kidney tissues, the expression of VEGI 174 was significantly lower in CCRCC (0.420 +/- 0.151 vs 0.107 +/- 0.063, p<0.01, respectively). On the contrary, MVD was higher in CCRCC specimens than in normal renal tissues (72.020 +/- 31.709 vs. 53.480 +/- 11.071, p<0.01, respectively). The expression of VEGI 174 in G1+G2 tumors was significantly higher than in G3 tumors (0.132 +/- 0.055 vs. 0.044 +/- 0.025, p<0.05, respectively). There was also a statistical significance in the expression of VEGI 174 in patients of different ages (<60y, 0.102 +/- 0.054 vs. >= 60 years, 0.117 +/- 9.083, p<0.01, respectively). However, between the staining of VEGI 174 and other pathological parameters (gender, tumour size and stage), there were no significant statistical differences (p>0.05). In addition, MVDs did not differ statistically by pathological grade, stage, gender, age or tumor size (p>0.05). Four patients died of CCRCC-related conditions during follow-up. However, no relationship between the expression of VEGI 174/MVD and overall survival was found in the study (p>0.05). Conclusion: VEGI 174 has a significant role in angiogenesis in CCRCC, and appears to be a negative regulator of aggressiveness during the development and progression of CCRCC.

语种英语
所属项目编号81072088
资助者National Natural Science Foundation of China ; Cancer Research Wales ; National Natural Science Foundation of China ; Cancer Research Wales
WOS记录号WOS:000331497200022
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55013
Collection北京大学临床肿瘤学院
作者单位1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Urol, Beijing 100020, Peoples R China
2.Cardiff Univ, Sch Med, Cardiff Univ Capital Med Univ Joint Ctr Biomed Re, Cardiff CF10 3AX, S Glam, Wales
3.Cent Hosp Hami, Dept Urol, Hami, Xinjiang Uygur, Peoples R China
4.Peoples Hosp Karamay, Dept Surg, Karamay, Xinjiang Uygur, Peoples R China
5.Capital Med Univ, Inst Canc, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
7.Capital Med Univ, Cardiff Univ Capital Med Univ Joint Ctr Biomed Re, Beijing, Peoples R China
8.Peking Univ, Canc Hosp, Dept Urol Oncol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wu, Liyang,Li, Xiaobei,Ye, Lin,et al. Vascular Endothelial Growth Inhibitor 174 Is a Negative Regulator of Aggressiveness and Microvascular Density in Human Clear Cell Renal Cell Carcinoma[J]. ANTICANCER RESEARCH,2014,34(2):715-722.
APA Wu, Liyang.,Li, Xiaobei.,Ye, Lin.,Shayiremu, Duoerkun.,Deng, Xiaohu.,...&Zhang, Ning.(2014).Vascular Endothelial Growth Inhibitor 174 Is a Negative Regulator of Aggressiveness and Microvascular Density in Human Clear Cell Renal Cell Carcinoma.ANTICANCER RESEARCH,34(2),715-722.
MLA Wu, Liyang,et al."Vascular Endothelial Growth Inhibitor 174 Is a Negative Regulator of Aggressiveness and Microvascular Density in Human Clear Cell Renal Cell Carcinoma".ANTICANCER RESEARCH 34.2(2014):715-722.
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