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IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China
作者: Gao, XH; Winsey, S; Li, G; Barnardo, M; Zhu, XJ; Chen, HD; Song, F; Zhai, N; Fuggle, S; Wojnarowska, F
刊名: CLINICAL AND EXPERIMENTAL DERMATOLOGY
发表日期: 2002-06-01
卷: 27, 期:4, 页:319-321
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: CLINICAL VARIANTS ; IDENTIFICATION ; SKIN
英文摘要:

Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP.

语种: 英语
WOS记录号: WOS:000177043200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55014
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China
2.Churchill Hosp, Dept Dermatol & Transplant Immunol, Oxford OX3 7LJ, England
3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Peoples R China

Recommended Citation:
Gao, XH,Winsey, S,Li, G,et al. HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2002,27(4):319-321.
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