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HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China
Gao, XH; Winsey, S; Li, G; Barnardo, M; Zhu, XJ; Chen, HD; Song, F; Zhai, N; Fuggle, S; Wojnarowska, F
刊名CLINICAL AND EXPERIMENTAL DERMATOLOGY
2002-06-01
27期:4页:319-321
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]CLINICAL VARIANTS ; IDENTIFICATION ; SKIN
英文摘要

Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP.

语种英语
WOS记录号WOS:000177043200018
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55014
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China
2.Churchill Hosp, Dept Dermatol & Transplant Immunol, Oxford OX3 7LJ, England
3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Peoples R China
推荐引用方式
GB/T 7714
Gao, XH,Winsey, S,Li, G,et al. HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2002,27(4):319-321.
APA Gao, XH.,Winsey, S.,Li, G.,Barnardo, M.,Zhu, XJ.,...&Wojnarowska, F.(2002).HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.CLINICAL AND EXPERIMENTAL DERMATOLOGY,27(4),319-321.
MLA Gao, XH,et al."HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China".CLINICAL AND EXPERIMENTAL DERMATOLOGY 27.4(2002):319-321.
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