北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China
作者: Gao, XH; Winsey, S; Li, G; Barnardo, M; Zhu, XJ; Chen, HD; Song, F; Zhai, N; Fuggle, S; Wojnarowska, F
刊名: CLINICAL AND EXPERIMENTAL DERMATOLOGY
发表日期: 2002-06-01
卷: 27, 期:4, 页:319-321
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: CLINICAL VARIANTS ; IDENTIFICATION ; SKIN
英文摘要:

Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP.

语种: 英语
WOS记录号: WOS:000177043200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55014
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China
2.Churchill Hosp, Dept Dermatol & Transplant Immunol, Oxford OX3 7LJ, England
3.China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Peoples R China

Recommended Citation:
Gao, XH,Winsey, S,Li, G,et al. HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2002,27(4):319-321.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, XH]'s Articles
[Winsey, S]'s Articles
[Li, G]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, XH]‘s Articles
[Winsey, S]‘s Articles
[Li, G]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace