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学科主题: 基础医学
题名:
Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People′s Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study
作者: Yang, Yu; Wang, Hua; Gong, Encong; Du, Juan; Zhao, Xishun; McNutt, Michael A.; Wang, Shenglan; Zhong, Yanfeng; Gao, Zifen; Zheng, Jie
关键词: Enterovirus type 71 ; Reverse transcription polymerase chain reaction ; Immunohistochemistry ; Hand, foot, and mouth disease
刊名: HUMAN PATHOLOGY
发表日期: 2009-09-01
DOI: 10.1016/j.humpath.2009.01.015
卷: 40, 期:9, 页:1288-1295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: MOUTH-DISEASE OUTBREAK ; CENTRAL-NERVOUS-SYSTEM ; PULMONARY-EDEMA ; LISTERIA-MONOCYTOGENES ; BRAIN-STEM ; TAIWAN ; HAND ; FOOT ; ENCEPHALOMYELITIS ; CHILDREN
英文摘要:

Between late March and June of 2008, an outbreak of hand, foot, and mouth disease caused by enterovirus 71 Occurred in China. In this outbreak, more than 176 000 cases occurred, and at least 40 people died. However, there has been no description of the neuropathologic features of fatal enterovirus 71 infection cases during this outbreak. We report postmortem studies in 2 fatal cases of enterovirus 7 1 infection with examination of the central nervous system using histopathology, immunohistochemistry, and reverse transcription polymerase chain reaction. Characteristic features of acute encephalitis were found predominantly in the brain stem and spinal cord. Abundant numbers of inflammatory cells with unusual irregularly rod-shaped and lobulated nuclei, which mimicked neutrophil morphology, were found both in abscess-like clusters associated with necrosis, as well as in inflammatory infiltrates. immunohistochemistry showed that most of these cells were CD68 positive and CD15 negative. Viral antigens were found in the cytoplasm of neurons, neuronal processes, and inflammatory cells, most often associated with glial nodules. The presence of enterovirus 71 was confirmed by reverse transcription polymerase chain reaction and sequencing. Results indicate that immunohistochemistry with CD68 and CD15 may offer some help in the differential diagnosis of brain stein encephalitis caused by enterovirus 71. Postmortem reverse transcription polymerase chain reaction from brain stein tissues, which have already undergone fixation and histologic processing, can be an important diagnostic tool, which may be of particular value in patients who may have been misdiagnosed clinically. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000269368800009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55020
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Beijing Autopsy Ctr, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Yu,Wang, Hua,Gong, Encong,et al. Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People′s Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study[J]. HUMAN PATHOLOGY,2009,40(9):1288-1295.
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