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学科主题: 药学
题名:
Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes
作者: Yu, Min2,3; Yang, Yang1; Han, Rongcheng2,3; Zheng, Qiang2,3; Wang, Lijun2,3; Hong, Yuankai2,3; Li, Zhongjun1; Sha, Yinlin2,3
刊名: LANGMUIR
发表日期: 2010-06-01
DOI: 10.1021/la904488w
卷: 26, 期:11, 页:8534-8539
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: BIOLOGICAL DETECTION ; STRONG INHIBITION ; CHOLERA-TOXIN ; CDSE QUANTUM ; NANOCRYSTALS ; GLUTATHIONE ; CDTE ; DERIVATIVES ; NANOPARTICLES ; LUMINESCENCE
英文摘要:

Oligosaccharides play crucial roles in many biorecognition processes by the so-called "cluster glycosidic effect". We here report a facile synthesis of lactose-CdSeS/ZnS quantum dot conjugate (Lac-QDs) by use of 1-thiol-beta-D-lactose via ligand exchange, which exhibits significantly high affinity and specificity to leukocytes in contrast to the monovalent lactose. Structural analyses indicate that there are about 132 lactosyl molecules assembled on single QDs and the hydrodynamic diameter is small, close to 8.2 am. Further. Lac-QDs display good fluorescence and physicochemical stability in physiological conditions, as well as extremely low cytotoxicity. These properties facilitate the use of Lac-QDs in fluorescent labeling of live leukocytes.

语种: 英语
所属项目编号: 20973008 ; 2007CB935801 ; 20673001 ; 90713004
项目资助者: NSFC ; 973 program
WOS记录号: WOS:000277928100117
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55024
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Min,Yang, Yang,Han, Rongcheng,et al. Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes[J]. LANGMUIR,2010,26(11):8534-8539.
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