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Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes
Yu, Min2,3; Yang, Yang1; Han, Rongcheng2,3; Zheng, Qiang2,3; Wang, Lijun2,3; Hong, Yuankai2,3; Li, Zhongjun1; Sha, Yinlin2,3
刊名LANGMUIR
2010-06-01
DOI10.1021/la904488w
26期:11页:8534-8539
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
资助者NSFC ; 973 program ; NSFC ; 973 program
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]BIOLOGICAL DETECTION ; STRONG INHIBITION ; CHOLERA-TOXIN ; CDSE QUANTUM ; NANOCRYSTALS ; GLUTATHIONE ; CDTE ; DERIVATIVES ; NANOPARTICLES ; LUMINESCENCE
英文摘要

Oligosaccharides play crucial roles in many biorecognition processes by the so-called "cluster glycosidic effect". We here report a facile synthesis of lactose-CdSeS/ZnS quantum dot conjugate (Lac-QDs) by use of 1-thiol-beta-D-lactose via ligand exchange, which exhibits significantly high affinity and specificity to leukocytes in contrast to the monovalent lactose. Structural analyses indicate that there are about 132 lactosyl molecules assembled on single QDs and the hydrodynamic diameter is small, close to 8.2 am. Further. Lac-QDs display good fluorescence and physicochemical stability in physiological conditions, as well as extremely low cytotoxicity. These properties facilitate the use of Lac-QDs in fluorescent labeling of live leukocytes.

语种英语
所属项目编号20973008 ; 2007CB935801 ; 20673001 ; 90713004
资助者NSFC ; 973 program ; NSFC ; 973 program
WOS记录号WOS:000277928100117
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55024
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, Min,Yang, Yang,Han, Rongcheng,et al. Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes[J]. LANGMUIR,2010,26(11):8534-8539.
APA Yu, Min.,Yang, Yang.,Han, Rongcheng.,Zheng, Qiang.,Wang, Lijun.,...&Sha, Yinlin.(2010).Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes.LANGMUIR,26(11),8534-8539.
MLA Yu, Min,et al."Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes".LANGMUIR 26.11(2010):8534-8539.
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